Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/87361
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Type: | Journal article |
Title: | Improved detection of helix-turn-helix DNA-binding motifs in protein sequences |
Author: | Dodd, I.B. Egan, J.B. |
Citation: | Nucleic Acids Research, 1990; 18(17):5019-5026 |
Publisher: | Oxford University Press |
Issue Date: | 1990 |
ISSN: | 0305-1048 1362-4962 |
Statement of Responsibility: | Ian B.Dodd and J.Barry Egan |
Abstract: | We present an update of our method for systematic detection and evaluation of potential hellx-turn-helix DNA-binding motifs in protein sequences [Dodd, I. and Egan, J. B. (1987) J. Mol. Biol. 194, 557-564]. The new method is considerably more powerful, detecting approximately 50% more likely hellx-turn-helix sequences without an Increase In false predictions. This improvement is due almost entirely to the use of a much larger reference set of 91 presumed helix-tumhellx sequences. The scoring matrix derived from this reference set has been calibrated against a large protein sequence database so that the score obtained by a sequence can be used to give a practical estimation of the probability that the sequence Is a helix-turn-helix motif. |
Keywords: | Animals DNA-Binding Proteins DNA Probability Amino Acid Sequence Protein Conformation Molecular Sequence Data Information Systems |
Rights: | © 1990 Oxford University Press |
DOI: | 10.1093/nar/18.17.5019 |
Published version: | http://dx.doi.org/10.1093/nar/18.17.5019 |
Appears in Collections: | Aurora harvest 7 Molecular and Biomedical Science publications |
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hdl_87361.pdf | Published version | 763.38 kB | Adobe PDF | View/Open |
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