Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/87432
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Outcome for esophageal cancer following treatment with chemotherapy and radiotherapy but not esophagectomy: nonsurgical treatment of esophageal cancer |
Author: | Zingg, U. DiValentino, D. McQuinn, A. Mardzuki, A. Thompson, S. Karapetis, C.S. Watson, D.I. |
Citation: | Clinical and Experimental Gastroenterology, 2009; 2009(2):75-83 |
Publisher: | Dove Medical Press |
Issue Date: | 2009 |
ISSN: | 1178-7023 1178-7023 |
Statement of Responsibility: | Urs Zingg, Dennis DiValentino, Alexander McQuinn, Ahmad Mardzuki, Sarah K Thompson, Christos S Karapetis, David I Watson |
Abstract: | Background: More than 50% of patients with esophageal cancer are not suitable for surgery. The aim of this study was to analyze the outcome of patients undergoing standard nonsurgical treatment. Methods: Data of all patients undergoing nonsurgical treatment for esophageal cancer were identified from a prospective database. Results: Seventy-five patients were treated for localized disease, and 52 for metastatic disease at diagnosis. Except for age, which was higher in patients without metastases, there were no significant differences between the patients with vs. without metastatic disease. Kaplan–Meier analysis showed a median survival of 10.8 months for all patients. There was a significant difference in survival (p < 0.001) between the groups with versus without metastases, with median survival in the patients without metastases 13.6 months versus 6.5 months in patients with metastases. Patients undergoing nonsurgical treatment for localized disease had a five-year survival of 12%. No significant difference between adenocarcinoma and squamous cell carcinoma was identified. Subanalysis of patients who received chemoradiotherapy revealed similar results to the overall group of patients. Conclusion: In patients with localized disease at diagnosis, long-term survival can be achieved in some patients, whereas five-year survival is rare in patients who present with metastatic disease. |
Keywords: | nonsurgical treatment esophageal cancer chemoradiotherapy metastases survival |
Rights: | This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
DOI: | 10.2147/CEG.S6273 |
Published version: | http://dx.doi.org/10.2147/ceg.s6273 |
Appears in Collections: | Aurora harvest 2 Surgery publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_87432.pdf | Published version | 320.29 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.