Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/88162
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Prediction of neonatal metabolic acidosis in women with a singleton term pregnancy in cephalic presentation: an external validation study |
Author: | Schuit, E. Amer-Wahlin, I. Groenwold, R. Mol, B. Moons, K. Kwee, A. |
Citation: | American Journal of Perinatology: neonatal and maternal-fetal medicine, 2012; 29(9):681-686 |
Publisher: | Thieme Medical |
Issue Date: | 2012 |
ISSN: | 0735-1631 1938-2480 |
Statement of Responsibility: | Ewoud Schuit, Isis Amer-Wahlin, Rolf H.H. Groenwold, Ben W.J. Mol, Karel G.M. Moons, Anneke Kwee |
Abstract: | Objective: To externally validate two previously developed prognostic models that predict the risk for developing metabolic acidosis in newborns using both antepartum (model 1) and intrapartum (combined with antepartum, model 2) risk factors: parity, previous cesarean section, maternal diabetes mellitus, gestational age, induced onset of labor, meconium-stained amniotic fluid, and use of ST analysis. Study Design: The two prediction models were applied in women in active labor at more than 36 gestational weeks with singleton fetuses in cephalic presentation and with high-risk pregnancies (n = 5049) who were included in a Swedish randomized trial between December 1, 1998, and June 4, 2000. The prognostic ability of the models was determined using calibration and discrimination measures. Results: Of 5049 infants in the validation population, 54 (1.1%) suffered from metabolic acidosis. After adjustment for incidence differences between the Dutch and Swedish cohorts, the prognostic models showed good calibration and moderate overall discrimination (C statistic 0.63, 95% confidence interval [CI] 0.55 to 0.71; and 0.64, 95% CI 0.55 to 0.72), for models 1 and 2, respectively). Conclusion: External validation of the clinical prediction models for metabolic acidosis in Swedish infants showed good calibration and moderate discriminative ability. Updating of the models to enhance their predictive abilities seems indicated. |
Keywords: | metabolic acidosis; external validation; prognostic model; birth asphyxia; neonate |
Rights: | © Georg Thieme Verlag |
DOI: | 10.1055/s-0032-1314888 |
Published version: | http://dx.doi.org/10.1055/s-0032-1314888 |
Appears in Collections: | Aurora harvest 7 Obstetrics and Gynaecology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.