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https://hdl.handle.net/2440/88170
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Type: | Journal article |
Title: | Adherence and motility characteristics of clinical Acinetobacter baumannii isolates |
Author: | Eijkelkamp, B. Stroeher, U. Hassan, K. Papadimitrious, M. Paulsen, I. Brown, M. |
Citation: | FEMS Microbiology Letters, 2011; 323(1):44-51 |
Publisher: | Blackwell Publishing |
Issue Date: | 2011 |
ISSN: | 0378-1097 1574-6968 |
Editor: | Lo, R. |
Statement of Responsibility: | Bart A. Eijkelkamp, Uwe H. Stroeher, Karl A. Hassan, Michael S. Papadimitrious, Ian T. Paulsen, and Melissa H. Brown |
Abstract: | Acinetobacter baumannii continues to be a major health problem especially in hospital settings. Herein, features that may play a role in persistence and disease potential were investigated in a collection of clinical A. baumannii strains from Australia. Twitching motility was found to be a common trait in A. baumannii international clone I strains and in abundant biofilm formers, whereas swarming motility was only observed in isolates not classified within the international clone lineages. Bioinformatic analysis of the type IV fimbriae revealed a correlation between PilA sequence homology and motility. A high level of variability in adherence to both abiotic surfaces and epithelial cells was found. We report for the first time the motility characteristics of a large number of A. baumannii isolates and present a direct comparison of A. baumannii binding to nasopharyngeal and lung epithelial cells. |
Keywords: | twitching; swarming; eukaryotic cell adherence; biofilm formation; type IV pili; Australian clinical strains |
Rights: | © 2011 Federation of European Microbiological Societies |
DOI: | 10.1111/j.1574-6968.2011.02362.x |
Published version: | http://dx.doi.org/10.1111/j.1574-6968.2011.02362.x |
Appears in Collections: | Aurora harvest 7 Molecular and Biomedical Science publications |
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