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https://hdl.handle.net/2440/88481
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dc.contributor.author | Bradfield, J. | - |
dc.contributor.author | Taal, H. | - |
dc.contributor.author | Timpson, N. | - |
dc.contributor.author | Scherag, A. | - |
dc.contributor.author | Lecoeur, C. | - |
dc.contributor.author | Warrington, N. | - |
dc.contributor.author | Hypponen, E. | - |
dc.contributor.author | Holst, C. | - |
dc.contributor.author | Valcarcel, B. | - |
dc.contributor.author | Thiering, E. | - |
dc.contributor.author | Salem, R. | - |
dc.contributor.author | Schumacher, F. | - |
dc.contributor.author | Cousminer, D. | - |
dc.contributor.author | Sleiman, P. | - |
dc.contributor.author | Jianhua, Z. | - |
dc.contributor.author | Berkowitz, R. | - |
dc.contributor.author | Vimaleswaran, K. | - |
dc.contributor.author | Ivonne, J. | - |
dc.contributor.author | Pennell, C. | - |
dc.contributor.author | Evans, D. | - |
dc.contributor.author | et al. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Nature Genetics, 2012; 44(5):526-531 | - |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.issn | 1546-1718 | - |
dc.identifier.uri | http://hdl.handle.net/2440/88481 | - |
dc.description.abstract | Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10−6 in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 × 10−9; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 × 10−9; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI. | - |
dc.description.statementofresponsibility | Jonathan P Bradfield ... Lyle J Palmer ... et al. for the Early Growth Genetics (EGG) Consortium | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.rights | © 2012 Nature America, Inc. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1038/ng.2247 | - |
dc.subject | Early Growth Genetics Consortium | - |
dc.subject | Humans | - |
dc.subject | Obesity | - |
dc.subject | Genetic Predisposition to Disease | - |
dc.subject | Genetic Markers | - |
dc.subject | Body Mass Index | - |
dc.subject | Case-Control Studies | - |
dc.subject | Polymorphism, Single Nucleotide | - |
dc.subject | Adolescent | - |
dc.subject | Adult | - |
dc.subject | Genome-Wide Association Study | - |
dc.subject | Young Adult | - |
dc.subject | Genetic Loci | - |
dc.title | A genome-wide association meta-analysis identifies new childhood obesity loci | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/ng.2247 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/403981 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 2 Translational Health Science publications |
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