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https://hdl.handle.net/2440/8859
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Type: | Journal article |
Title: | Acute hyperglycaemia affects anorectal motor and sensory function in normal subjects |
Author: | Russo, A. Sun, W.M. Sattawatthamrong, Y. Fraser, R. Horowitz, M. Boeckxstaens, G. Andrews, J. Read, N. |
Citation: | Gut, 1997; 41(4):494-499 |
Publisher: | BRITISH MED JOURNAL PUBL GROUP |
Issue Date: | 1997 |
ISSN: | 0017-5749 1468-3288 |
Statement of Responsibility: | A Russo, W M Sun, Y Sattawatthamrong, R Fraser, M Horowitz, J M Andrews, N W Read |
Abstract: | <h4>Background</h4>The pathogenesis of anorectal dysfunction, which occurs frequently in patients with diabetes mellitus, is poorly defined. Recent studies indicate that changes in the blood glucose concentration have a major reversible effect on gastrointestinal motor function.<h4>Aims</h4>To determine the effects of physiological changes in blood glucose and hyperglycaemia on anorectal motor and sensory function in normal subjects.<h4>Subjects</h4>In eight normal subjects measurements of anorectal motility and sensation were performed on separate days while blood glucose concentrations were stabilised at 4, 8, and 12 mmol/l.<h4>Methods</h4>Anorectal motor and sensory function was measured using a sleeve/sidehole catheter incorporating a balloon, and electromyography.<h4>Results</h4>The number of spontaneous anal relaxations was greater at 12 mmol/l than at 8 and 4 mmol/l glucose (p < 0.05 for both). Anal squeeze pressures were less at a blood glucose of 12 mmol/l when compared with 8 and 4 mmol/l (p < 0.05 for both). During rectal distension, residual anal pressures were not significantly different between the three blood glucose concentrations. Rectal compliance was greater (p < 0.05) at a blood glucose of 12 mmol/l when compared with 4 mmol/l. The threshold volume for initial perception of rectal distension was less at 12 mmol/l when compared with 4 mmol/l (40 (20-100) ml versus 10 (10-150) ml, p < 0.05).<h4>Conclusions</h4>An acute elevation of blood glucose to 12 mmol/l inhibits internal and external anal sphincter function and increases rectal sensitivity in normal subjects. In contrast, physiological changes in blood glucose do not have a significant effect on anorectal motor and sensory function. |
Keywords: | Rectum Humans Hyperglycemia Acute Disease Glucose Clamp Technique Analysis of Variance Statistics, Nonparametric Single-Blind Method Manometry Sensory Thresholds Gastrointestinal Motility Adolescent Adult Middle Aged Anal Canal Male |
DOI: | 10.1136/gut.41.4.494 |
Published version: | http://dx.doi.org/10.1136/gut.41.4.494 |
Appears in Collections: | Aurora harvest Medicine publications |
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