Adelaide Research & Scholarship
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https://hdl.handle.net/2440/88828
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| Type: | Journal article |
| Title: | XMRV and prostate cancer - a 'final' perspective |
| Author: | Sfanos, K.S. Aloia, A.L. De Marzo, A.M. Rein, A. |
| Citation: | Nature Reviews Urology, 2012; 9(2):111-118 |
| Publisher: | Nature Publishing Group |
| Issue Date: | 2012 |
| ISSN: | 1759-4812 1759-4820 |
| Statement of Responsibility: | Karen S. Sfanos, Amanda L. Aloia, Angelo M. De Marzo & Alan Rein |
| Abstract: | XMRV was first described in 2006, when it was identified in samples isolated from prostate cancer tissues. However, studies have since shown that XMRV arose in the laboratory and was formed by genetic recombination between two viral genomes carried in the germline DNA of mice used during serial transplantation of the CWR22 prostate cancer xenograft. These new findings strongly imply that XMRV does not circulate in humans, but is only present in the laboratory. Thus, there is no reason to believe that it has any role in the etiology of prostate cancer or other diseases. |
| Keywords: | Animals Humans Prostatic Neoplasms DNA, Viral Male Xenotropic murine leukemia virus-related virus |
| Rights: | © 2012 Macmillan Publishers Limited. All rights reserved. |
| DOI: | 10.1038/nrurol.2011.225 |
| Published version: | http://dx.doi.org/10.1038/nrurol.2011.225 |
| Appears in Collections: | Aurora harvest 7 Molecular and Biomedical Science publications |
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