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Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/88959
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dc.contributor.authorBrisch, R.-
dc.contributor.authorSaniotis, A.-
dc.contributor.authorWolf, R.-
dc.contributor.authorBielau, H.-
dc.contributor.authorBernstein, H.-
dc.contributor.authorSteiner, J.-
dc.contributor.authorBogerts, B.-
dc.contributor.authorBraun, K.-
dc.contributor.authorBraun, A.-
dc.contributor.authorJankowski, Z.-
dc.contributor.authorKumaratilake, J.-
dc.contributor.authorKumaritlake, J.-
dc.contributor.authorHenneberg, M.-
dc.contributor.authorGos, T.-
dc.date.issued2014-
dc.identifier.citationFrontiers in Psychiatry, 2014; 5(APR):47-1-47-11-
dc.identifier.issn1664-0640-
dc.identifier.issn1664-0640-
dc.identifier.urihttp://hdl.handle.net/2440/88959-
dc.description.abstractDopamine is an inhibitory neurotransmitter involved in the pathology of schizophrenia. The revised dopamine hypothesis states that dopamine abnormalities in the mesolimbic and prefrontal brain regions exist in schizophrenia. However, recent research has indicated that glutamate, GABA, acetylcholine, and serotonin alterations are also involved in the pathology of schizophrenia. This review provides an in-depth analysis of dopamine in animal models of schizophrenia and also focuses on dopamine and cognition. Furthermore, this review provides not only an overview of dopamine receptors and the antipsychotic effects of treatments targeting them but also an outline of dopamine and its interaction with other neurochemical models of schizophrenia. The roles of dopamine in the evolution of the human brain and human mental abilities, which are affected in schizophrenia patients, are also discussed.-
dc.description.statementofresponsibilityRalf Brisch, Arthur Saniotis, Rainer Wolf, Hendrik Bielau, Hans-Gert Bernstein, Johann Steiner, Bernhard Bogerts, Katharina Braun, Zbigniew Jankowski, Jaliya Kumaratilake, Maciej Henneberg, and Tomasz Gos-
dc.language.isoen-
dc.publisherFrontiers-
dc.rightsCopyright ©2014 Brisch, Saniotis, Wolf, Bielau, Bernstein, Steiner, Bogerts, Braun, Jankowski, Kumaratilake, Henneberg and Gos. This is an open-access article distributed under the terms of the Creative Commons Attribution License(CCBY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.-
dc.source.urihttp://dx.doi.org/10.3389/fpsyt.2014.00047-
dc.subjectanimal models of schizophrenia-
dc.subjectcannabis-
dc.subjectcognition-
dc.subjectdopamine-
dc.subjectdopamine receptors-
dc.subjectevolution of the human brain-
dc.subjectglutamate-
dc.subjectschizophrenia-
dc.titleThe role of dopamine in schizophrenia from a neurobiological and evolutionary perspective: old fashioned, but still in vogue-
dc.typeJournal article-
dc.identifier.doi10.3389/fpsyt.2014.00047-
pubs.publication-statusPublished-
dc.identifier.orcidSaniotis, A. [0000-0002-9708-6220]-
dc.identifier.orcidKumaratilake, J. [0000-0001-5904-7629]-
dc.identifier.orcidHenneberg, M. [0000-0003-1941-2286]-
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