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https://hdl.handle.net/2440/90358
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Type: | Journal article |
Title: | Accuracy of biopsy in subtyping periocular basal cell carcinoma |
Author: | Sun, M. Wu, A. Huilgo, S. Selva, D. |
Citation: | Ophthalmic Plastic and Reconstructive Surgery, 2015; 31(6):449-451 |
Publisher: | Lippincott, Williams & Wilkins |
Issue Date: | 2015 |
ISSN: | 0740-9303 1537-2677 |
Statement of Responsibility: | Michelle T. Sun, Albert Wu, Shyamala C. Huilgol, and Dinesh Selva |
Abstract: | PURPOSE: To determine the accuracy of initial biopsy in the diagnosis of basal cell carcinoma (BCC) histologic subtype. METHODS: Retrospective histopathologic review of patients with a diagnosis of primary periocular BCC from 2006 to 2013 inclusive. RESULTS: A total of 174 primary BCCs were identified. BCCs were classified as nodular, superficial, or aggressive (including mixed cases with an aggressive component). Punch biopsies were used in 41% of cases, while the remaining patients underwent shave or incision biopsies. The final histologic subtypes at excision were nodular (59%), superficial (7%), nodular and superficial (7%), and aggressive (51%). The overall concordance between the BCC subtype identified in the biopsy specimen and the subsequent excision specimen was 54%. In total, there were 51 cases (29%) of BCC, which included aggressive subtypes, of which 52% of initial biopsies failed to detect an aggressive component. There were 45 cases (26%) of mixed BCC, and an aggressive histologic subtype was present in 73% of these cases. CONCLUSIONS: The accuracy of initial biopsy for BCC histologic subtype at excision is highest for nodular BCC. For aggressive BCC, biopsy was able to detect the aggressive component in only 48% of cases. This may have implications for choice of treatment modality. |
Keywords: | Humans Carcinoma, Basal Cell Eyelid Neoplasms Skin Neoplasms Biopsy Retrospective Studies Reproducibility of Results |
Rights: | Copyright © 2015 The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc. |
DOI: | 10.1097/iop.0000000000000372 |
Published version: | http://dx.doi.org/10.1097/iop.0000000000000372 |
Appears in Collections: | Aurora harvest 7 Opthalmology & Visual Sciences publications |
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