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https://hdl.handle.net/2440/91486
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Type: | Journal article |
Title: | Systematic review and metaanalysis on nonclassic cardiovascular biomarkers after hypertensive pregnancy disorders |
Author: | Visser, S. Hermes, W. Ket, J. Otten, R. Van Pampus, M. Bloemenkamp, K. Franx, A. Mol, B. De Groot, C. |
Citation: | American Journal of Obstetrics and Gynecology, 2014; 211(4):373.e1-373.e9 |
Publisher: | Elsevier |
Issue Date: | 2014 |
ISSN: | 0002-9378 1097-6868 |
Statement of Responsibility: | Sanne Visser, Wietske Hermes, Johannes C.F. Ket, René H.J. Otten, Maria G. van Pampus, Kitty W.M. Bloemenkamp, Arie Franx, Ben W. Mol, Christianne J.M. de Groot |
Abstract: | OBJECTIVE: The aim of this study was to investigate which nonclassic cardiovascular biomarkers are associated with persistent endothelial dysfunction after pregnancy in women with a history of hypertensive pregnancy disorders compared with women with uncomplicated pregnancies. STUDY DESIGN: This was a systematic review and metaanalysis of observational studies. A search was performed in PubMed, Embase, Cochrane, and Cinahl including articles from inception to Feb. 27, 2013. Included were cohort studies and case-control studies. Cases were women with a history of hypertension in pregnancy, control subjects were women with a history of uncomplicated pregnancies. Of the 3136 found, 21 studies on 16 nonclassic cardiovascular biomarkers are described in this review; 12 studies on 5 biomarkers were included in the metaanalysis. RESULTS: Women with a history of hypertensive pregnancy disorders had a higher homocysteine level compared with women with a history of uncomplicated pregnancies (5 studies; pooled mean difference, 0.77 ng/mL; 95% confidence interval, 0.27-1.26; P < .01). For the other nonclassic cardiovascular biomarkers including markers in areas of inflammation, thrombosis, and angiogenesis, we found no significant differences. CONCLUSION: This review and metaanalysis showed that women with a history of hypertensive pregnancy disorders have higher homocysteine levels compared with women with a history of uncomplicated pregnancies. These data suggest persistent endothelial alteration after pregnancies complicated by hypertensive disorders. |
Keywords: | cardiovascular risk; hypertensive pregnancy disorders; preeclampsia; pregnancy-induced hypertension |
Rights: | © 2014 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.ajog.2014.03.032 |
Published version: | http://dx.doi.org/10.1016/j.ajog.2014.03.032 |
Appears in Collections: | Aurora harvest 7 Obstetrics and Gynaecology publications |
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