Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/92375
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jones, S. | - |
dc.contributor.author | Duncan, J. | - |
dc.contributor.author | Aitken, S. | - |
dc.contributor.author | Coxon, J. | - |
dc.contributor.author | Abell, A. | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Australian Journal of Chemistry: an international journal for chemical science, 2014; 67(9):1257-1263 | - |
dc.identifier.issn | 0004-9425 | - |
dc.identifier.issn | 1445-0038 | - |
dc.identifier.uri | http://hdl.handle.net/2440/92375 | - |
dc.description.abstract | Ring closing metathesis and cross metathesis approaches to a new macrocyclic peptidomimetic aldehyde 2 have been developed, with the former route being the most convenient. Aldehyde 2 is a potent inhibitor of calpain II (IC50 of 45 nM) with comparable activity to the benchmark acyclic inhibitor SJA6017 4. Both compounds contain an N-terminal 4-fluorophenylsulfonyl group. The P2 Ile analogue of 2 (16) is significantly less active (IC50 of 2000 nM) which reflects an unusually subtle importance of the P2 residue for active site binding. | - |
dc.description.statementofresponsibility | Seth A. Jones, Joanna Duncan, Steven G. Aitken, James M. Coxon and Andrew D. Abell | - |
dc.language.iso | en | - |
dc.publisher | CSIRO | - |
dc.rights | Copyright status unknown | - |
dc.source.uri | http://dx.doi.org/10.1071/ch14121 | - |
dc.title | The preparation of macrocyclic calpain inhibitors by ring closing metathesis and cross metathesis | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1071/CH14121 | - |
dc.relation.grant | ARC | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Abell, A. [0000-0002-0604-2629] | - |
Appears in Collections: | Aurora harvest 7 IPAS publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.