Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/92586
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Type: Journal article
Title: Oestrogen hormone receptors in focal nodular hyperplasia
Author: Chandrasegaram, M.
Shah, A.
Chen, J.
Ruszkiewicz, A.
Astill, D.
England, G.
Raju, R.
Neo, E.
Dolan, P.
Tan, C.
Brooke-Smith, M.
Wilson, T.
Padbury, R.
Worthley, C.
Citation: Hepato Pancreato Biliary, 2015; 17(6):502-507
Publisher: Blackwell Publishing
Issue Date: 2015
ISSN: 1365-182X
1477-2574
Statement of
Responsibility: 
Manju D. Chandrasegaram, Ali Shah, John W. Chen, Andrew Ruszkiewicz, David S. Astill, Georgina England, Ravish S. Raju, Eu Ling Neo, Paul M. Dolan, Chuan Ping Tan, Mark Brooke-Smith, Tom Wilson, Robert T. A. Padbury, and Christopher S. Worthley
Abstract: BACKGROUND: The role of hormones in focal nodular hyperplasia (FNH) has been investigated with conflicting results. OBJECTIVE: The aim of this study was to evaluate oestrogen and progesterone receptor immunohistochemical expression in FNH and surrounding normal liver (control material). METHODS: Biopsy materials from FNH and control tissue were investigated using an immunostainer. Receptor expression was graded as the proportion score (percentage of nuclear staining) and oestrogen receptor intensity score. RESULTS: Study material included tissue from 11 resected FNH lesions and two core biopsies in 13 patients (two male). Twelve samples showed oestrogen receptor expression. The percentage of nuclear oestrogen receptor staining was <33% in eight FNH biopsies, 34-66% in two FNH biopsies, and >67% in both core biopsies. The better staining in core biopsies relates to limitations of the staining technique imposed by the fibrous nature of larger resected FNH. Control samples from surrounding tissue were available for nine of the resected specimens and all showed oestrogen receptor expression. Progesterone receptor expression was negligible in FNH and control samples. CONCLUSIONS: By contrast with previous studies, the majority of FNH and surrounding liver in this cohort demonstrated oestrogen receptor nuclear staining. The implications of this for continued oral contraceptive use in women of reproductive age with FNH remain uncertain given the lack of consistent reported growth response to oestrogen stimulation or withdrawal.
Keywords: Liver
Cell Nucleus
Humans
Focal Nodular Hyperplasia
Contraceptives, Oral, Hormonal
Receptors, Estrogen
Receptors, Progesterone
Biopsy
Hepatectomy
Immunohistochemistry
Predictive Value of Tests
Adult
Middle Aged
Female
Male
Rights: © 2015 International Hepato-Pancreato-Biliary Association
DOI: 10.1111/hpb.12387
Published version: http://dx.doi.org/10.1111/hpb.12387
Appears in Collections:Aurora harvest 7
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