Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/94654
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Type: | Journal article |
Title: | PINA v2.0: mining interactome modules |
Author: | Cowley, M. Pinese, M. Kassahn, K. Waddell, N. Pearson, J. Grimmond, S. Biankin, A. Hautaniemi, S. Wu, J. |
Citation: | Nucleic Acids Research, 2011; 40(D1):D862-D865 |
Publisher: | Oxford University Press |
Issue Date: | 2011 |
ISSN: | 0305-1048 1362-4962 |
Statement of Responsibility: | Mark J. Cowley, Mark Pinese, Karin S. Kassahn, Nic Waddell, John V. Pearson, Sean M. Grimmond, Andrew V. Biankin, Sampsa Hautaniemi, and Jianmin Wu |
Abstract: | The Protein Interaction Network Analysis (PINA) platform is a comprehensive web resource, which includes a database of unified protein–protein interaction data integrated from six manually curated public databases, and a set of built-in tools for network construction, filtering, analysis and visualization. The second version of PINA enhances its utility for studies of protein interactions at a network level, by including multiple collections of interaction modules identified by different clustering approaches from the whole network of protein interactions (‘interactome’) for six model organisms. All identified modules are fully annotated by enriched Gene Ontology terms, KEGG pathways, Pfam domains and the chemical and genetic perturbations collection from MSigDB. Moreover, a new tool is provided for module enrichment analysis in addition to simple query function. The interactome data are also available on the web site for further bioinformatics analysis. PINA is freely accessible at http://cbg.garvan.unsw.edu.au/pina/. |
Rights: | © The Author(s) 2011. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1093/nar/gkr967 |
Published version: | http://dx.doi.org/10.1093/nar/gkr967 |
Appears in Collections: | Aurora harvest 3 Ecology, Evolution and Landscape Science publications |
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hdl_94654.pdf | Published version | 3.81 MB | Adobe PDF | View/Open |
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