Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/9589
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Type: Journal article
Title: Effect of variations in small intestinal glucose delivery on plasma glucose, insulin, and incretin hormones in healthy subjects and type 2 diabetes
Author: O'Donovan, D.
Doran, S.
Feinle-Bisset, C.
Jones, K.
Meyer, J.
Wishart, J.
Morris, H.
Horowitz, M.
Citation: Journal of Clinical Endocrinology and Metabolism, 2004; 89(7):3431-3435
Publisher: Endocrine Society
Issue Date: 2004
ISSN: 0021-972X
1945-7197
Statement of
Responsibility: 
Deirdre G. O’Donovan, Selena Doran, Christine Feinle-Bisset, Karen L. Jones, James H. Meyer, Judith M. Wishart, Howard A. Morris and Michael Horowitz
Abstract: The determinants of postprandial blood glycemia are controversial. We assessed the effects of variations in the initial rate of small intestinal glucose delivery on blood glucose, plasma insulin, and incretin responses in both health and type 2 diabetes. Eight controls and eight patients with type 2 diabetes managed by diet alone underwent paired studies. On both days subjects received an intraduodenal glucose infusion (t = 0–120 min); on one day the infusion rate was variable, being more rapid initially (3 kcal/min) between t = 0 and 15 min and slower (0.71 kcal/min) subsequently (t = 15–120 min), whereas on the other day, the infusion rate was constant (1 kcal/min) from t = 0 to 120 min (i.e. on both days 120 kcal of glucose were administered). Between t = 0–180 min blood glucose, plasma insulin and plasma glucose-dependent insulin-releasing polypeptide were greater with the variable, compared with the constant, infusion. Between t = 0 and 30 min the magnitude of the rise in plasma glucagon-like peptide-1 was greater with the variable, compared with the constant infusion (P < 0.01, both groups). We conclude that modest variations in the initial rate of duodenal glucose entry may have profound effects on subsequent glycemic, insulin, and incretin responses.
Keywords: Intestine, Small
Duodenum
Humans
Diabetes Mellitus, Type 2
Gastric Inhibitory Polypeptide
Glucagon
Insulin
Glucose
Blood Glucose
Peptide Fragments
Protein Precursors
Case-Control Studies
Biological Availability
Osmolar Concentration
Middle Aged
Female
Glucagon-Like Peptide 1
Description: Copyright © 2004 by The Endocrine Society
DOI: 10.1210/jc.2004-0334
Published version: http://jcem.endojournals.org/cgi/content/abstract/89/7/3431
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