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https://hdl.handle.net/2440/97154
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Type: | Journal article |
Title: | Development of mammalian ovary |
Author: | Smith, P. Wilhelm, D. Rodgers, R.J. |
Citation: | Journal of Endocrinology, 2014; 221(3):R145-R161 |
Publisher: | Bioscientifica Ltd |
Issue Date: | 2014 |
ISSN: | 0022-0795 1479-6805 |
Statement of Responsibility: | Peter Smith, Dagmar Wilhelm, and Raymond J Rodgers |
Abstract: | Pre-natal and early post-natal ovarian development has become a field of increasing importance over recent years. The full effects of perturbations of ovarian development on adult fertility, through environmental changes or genetic anomalies, are only now being truly appreciated. Mitigation of these perturbations requires an understanding of the processes involved in the development of the ovary. Herein, we review some recent findings from mice, sheep, and cattle on the key events involved in ovarian development. We discuss the key process of germ cell migration, ovigerous cord formation, meiosis, and follicle formation and activation. We also review the key contributions of mesonephric cells to ovarian development and propose roles for these cells. Finally, we discuss polycystic ovary syndrome, premature ovarian failure, and pre-natal undernutrition; three key areas in which perturbations to ovarian development appear to have major effects on post-natal fertility. |
Keywords: | ovary; fetus; development; polycystic ovary syndrome; premature ovary failure |
Rights: | © 2014 Society for Endocrinology |
DOI: | 10.1530/JOE-14-0062 |
Grant ID: | ARC |
Published version: | http://dx.doi.org/10.1530/joe-14-0062 |
Appears in Collections: | Aurora harvest 7 Medical Sciences publications |
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