Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/99332
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Type: | Journal article |
Title: | The periconceptional environment and cardiovascular disease: does in vitro embryo culture and transfer influence cardiovascular development and health? |
Author: | Padhee, M. Zhang, S. Lie, S. Wang, K. Botting, K. Caroline McMillen, I. Maclaughlin, S. Morrison, J. |
Citation: | Nutrients, 2015; 7(3):1378-1425 |
Publisher: | MDPI AG |
Issue Date: | 2015 |
ISSN: | 2072-6643 2072-6643 |
Statement of Responsibility: | Monalisa Padhee, Song Zhang, Shervi Lie, Kimberley C. Wang, Kimberley J. Botting, I. Caroline McMillen, Severence M. MacLaughlin and Janna L. Morrison |
Abstract: | Assisted Reproductive Technologies (ARTs) have revolutionised reproductive medicine; however, reports assessing the effects of ARTs have raised concerns about the immediate and long-term health outcomes of the children conceived through ARTs. ARTs include manipulations during the periconceptional period, which coincides with an environmentally sensitive period of gamete/embryo development and as such may alter cardiovascular development and health of the offspring in postnatal life. In order to identify the association between ARTs and cardiovascular health outcomes, it is important to understand the events that occur during the periconceptional period and how they are affected by procedures involved in ARTs. This review will highlight the emerging evidence implicating adverse cardiovascular outcomes before and after birth in offspring conceived through ARTs in both human and animal studies. In addition, it will identify the potential underlying causes and molecular mechanisms responsible for the congenital and adult cardiovascular dysfunctions in offspring whom were conceived through ARTs. |
Keywords: | Assisted reproductive technology; in vitro fertilization; periconceptional period; cardiovascular disease; epigenetics |
Rights: | © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
DOI: | 10.3390/nu7031378 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1066916 |
Published version: | http://dx.doi.org/10.3390/nu7031378 |
Appears in Collections: | Aurora harvest 7 Obstetrics and Gynaecology publications |
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hdl_99332.pdf | Published version | 1.09 MB | Adobe PDF | View/Open |
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