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https://hdl.handle.net/2440/99848
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Type: | Journal article |
Title: | Streptococcal toxins: role in pathogenesis and disease |
Author: | Barnett, T. Cole, J. Rivera-Hernandez, T. Henningham, A. Paton, J. Nizet, V. Walker, M. |
Citation: | Cellular Microbiology, 2015; 17(12):1721-1741 |
Publisher: | Wiley-Blackwell |
Issue Date: | 2015 |
ISSN: | 1462-5814 1462-5822 |
Statement of Responsibility: | Timothy C. Barnett, Jason N. Cole, Tania Rivera-Hernandez, Anna Henningham, James C. Paton, Victor Nizet and Mark J. Walker |
Abstract: | Group A Streptococcus (Streptococcus pyogenes), group B Streptococcus (Streptococcus agalactiae) and Streptococcus pneumoniae (pneumococcus) are host-adapted bacterial pathogens among the leading infectious causes of human morbidity and mortality. These microbes and related members of the genus Streptococcus produce an array of toxins that act against human cells or tissues, resulting in impaired immune responses and subversion of host physiological processes to benefit the invading microorganism. This toxin repertoire includes haemolysins, proteases, superantigens and other agents that ultimately enhance colonization and survival within the host and promote dissemination of the pathogen. |
Keywords: | Humans Streptococcus agalactiae Streptococcus pneumoniae Streptococcus pyogenes Streptococcal Infections Bacterial Toxins Virulence Factors Host-Pathogen Interactions |
Rights: | © 2015 John Wiley & Sons Ltd |
DOI: | 10.1111/cmi.12531 |
Grant ID: | NHMRC |
Published version: | http://dx.doi.org/10.1111/cmi.12531 |
Appears in Collections: | Aurora harvest 7 Microbiology and Immunology publications |
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