Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/99848
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Type: Journal article
Title: Streptococcal toxins: role in pathogenesis and disease
Author: Barnett, T.
Cole, J.
Rivera-Hernandez, T.
Henningham, A.
Paton, J.
Nizet, V.
Walker, M.
Citation: Cellular Microbiology, 2015; 17(12):1721-1741
Publisher: Wiley-Blackwell
Issue Date: 2015
ISSN: 1462-5814
1462-5822
Statement of
Responsibility: 
Timothy C. Barnett, Jason N. Cole, Tania Rivera-Hernandez, Anna Henningham, James C. Paton, Victor Nizet and Mark J. Walker
Abstract: Group A Streptococcus (Streptococcus pyogenes), group B Streptococcus (Streptococcus agalactiae) and Streptococcus pneumoniae (pneumococcus) are host-adapted bacterial pathogens among the leading infectious causes of human morbidity and mortality. These microbes and related members of the genus Streptococcus produce an array of toxins that act against human cells or tissues, resulting in impaired immune responses and subversion of host physiological processes to benefit the invading microorganism. This toxin repertoire includes haemolysins, proteases, superantigens and other agents that ultimately enhance colonization and survival within the host and promote dissemination of the pathogen.
Keywords: Humans
Streptococcus agalactiae
Streptococcus pneumoniae
Streptococcus pyogenes
Streptococcal Infections
Bacterial Toxins
Virulence Factors
Host-Pathogen Interactions
Rights: © 2015 John Wiley & Sons Ltd
DOI: 10.1111/cmi.12531
Grant ID: NHMRC
Published version: http://dx.doi.org/10.1111/cmi.12531
Appears in Collections:Aurora harvest 7
Microbiology and Immunology publications

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