Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/101042
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dc.contributor.authorLuscombe-Marsh, N.-
dc.contributor.authorHutchison, A.-
dc.contributor.authorSoenen, S.-
dc.contributor.authorSteinert,-
dc.contributor.authorClifton,-
dc.contributor.authorHorowitz,-
dc.contributor.authorFeinle-Bisset,-
dc.date.issued2016-
dc.identifier.citationNutrients, 2016; 8(1):4-1-4-13-
dc.identifier.issn2072-6643-
dc.identifier.issn2072-6643-
dc.identifier.urihttp://hdl.handle.net/2440/101042-
dc.description.abstractThis study determined the effects of increasing loads of intraduodenal (ID) dairy protein on plasma amino acid (AA) concentrations, and their relationships with serum insulin, plasma glucagon-like peptide-1 (GLP-1) and energy intake. Sixteen healthy men had concentrations of AAs, GLP-1 and insulin measured in response to 60-min ID infusions of hydrolysed whey protein administered, in double-blinded and randomised order, at 2.1 (P2.1), 6.3 (P6.3) or 12.5 (P12.5) kJ/min (encompassing the range of nutrient emptying from the stomach), or saline control (C). Energy intake was quantified immediately afterwards. Compared with C, the concentrations of 19/20 AAs, the exception being cysteine, were increased, and this was dependent on the protein load. The relationship between AA concentrations in the infusions and the area under the curve from 0 to 60 min (AUC0-60 min) of each AA profile was strong for essential AAs (R² range, 0.61–0.67), but more variable for non-essential (0.02–0.54) and conditional (0.006–0.64) AAs. The AUC0 60 min for each AA was correlated directly with the AUC0-60 min of insulin (R² range 0.3–0.6), GLP-1 (0.2–0.6) and energy intake (0.09–0.3) (p < 0.05, for all), with the strongest correlations being for branched-chain AAs, lysine, methionine and tyrosine. These findings indicate that ID whey protein infused at loads encompassing the normal range of gastric emptying increases plasma concentrations of 19/20 AAs in a load-dependent manner, and provide novel information on the close relationships between the essential AAs, leucine, valine, isoleucine, lysine, methionine, and the conditionally-essential AA, tyrosine, with energy intake, insulin and GLP-1.-
dc.description.statementofresponsibilityNatalie D. Luscombe-Marsh, Amy T. Hutchison, Stijn Soenen, Robert E. Steinert, Peter M. Clifton, Michael Horowitz and Christine Feinle-Bisset-
dc.language.isoen-
dc.publisherMDPI AG-
dc.rights© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).-
dc.source.urihttp://dx.doi.org/10.3390/nu8010004-
dc.subjectDairy; whey protein hydrolysate; insulinotropic response; glycemic control; appetite regulation; human-
dc.titlePlasma free amino acid responses to intraduodenal whey protein and relationships with insulin, glucagon-like peptide-1 and energy intake in lean healthy men-
dc.typeJournal article-
dc.identifier.doi10.3390/nu8010004-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/627118-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1020594-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/627002-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1103020-
pubs.publication-statusPublished-
dc.identifier.orcidLuscombe-Marsh, N. [0000-0001-9690-4722]-
dc.identifier.orcidHutchison, A. [0000-0002-6393-3671]-
dc.identifier.orcidSoenen, S. [0000-0002-0196-128X]-
dc.identifier.orcidClifton, [0000-0002-6411-626X]-
dc.identifier.orcidHorowitz, [0000-0002-0942-0306]-
dc.identifier.orcidFeinle-Bisset, [0000-0001-6848-0125]-
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