Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/101042
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dc.contributor.author | Luscombe-Marsh, N. | - |
dc.contributor.author | Hutchison, A. | - |
dc.contributor.author | Soenen, S. | - |
dc.contributor.author | Steinert, | - |
dc.contributor.author | Clifton, | - |
dc.contributor.author | Horowitz, | - |
dc.contributor.author | Feinle-Bisset, | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Nutrients, 2016; 8(1):4-1-4-13 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | http://hdl.handle.net/2440/101042 | - |
dc.description.abstract | This study determined the effects of increasing loads of intraduodenal (ID) dairy protein on plasma amino acid (AA) concentrations, and their relationships with serum insulin, plasma glucagon-like peptide-1 (GLP-1) and energy intake. Sixteen healthy men had concentrations of AAs, GLP-1 and insulin measured in response to 60-min ID infusions of hydrolysed whey protein administered, in double-blinded and randomised order, at 2.1 (P2.1), 6.3 (P6.3) or 12.5 (P12.5) kJ/min (encompassing the range of nutrient emptying from the stomach), or saline control (C). Energy intake was quantified immediately afterwards. Compared with C, the concentrations of 19/20 AAs, the exception being cysteine, were increased, and this was dependent on the protein load. The relationship between AA concentrations in the infusions and the area under the curve from 0 to 60 min (AUC0-60 min) of each AA profile was strong for essential AAs (R² range, 0.61–0.67), but more variable for non-essential (0.02–0.54) and conditional (0.006–0.64) AAs. The AUC0 60 min for each AA was correlated directly with the AUC0-60 min of insulin (R² range 0.3–0.6), GLP-1 (0.2–0.6) and energy intake (0.09–0.3) (p < 0.05, for all), with the strongest correlations being for branched-chain AAs, lysine, methionine and tyrosine. These findings indicate that ID whey protein infused at loads encompassing the normal range of gastric emptying increases plasma concentrations of 19/20 AAs in a load-dependent manner, and provide novel information on the close relationships between the essential AAs, leucine, valine, isoleucine, lysine, methionine, and the conditionally-essential AA, tyrosine, with energy intake, insulin and GLP-1. | - |
dc.description.statementofresponsibility | Natalie D. Luscombe-Marsh, Amy T. Hutchison, Stijn Soenen, Robert E. Steinert, Peter M. Clifton, Michael Horowitz and Christine Feinle-Bisset | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.rights | © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). | - |
dc.source.uri | http://dx.doi.org/10.3390/nu8010004 | - |
dc.subject | Dairy; whey protein hydrolysate; insulinotropic response; glycemic control; appetite regulation; human | - |
dc.title | Plasma free amino acid responses to intraduodenal whey protein and relationships with insulin, glucagon-like peptide-1 and energy intake in lean healthy men | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.3390/nu8010004 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/627118 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1020594 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/627002 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1103020 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Luscombe-Marsh, N. [0000-0001-9690-4722] | - |
dc.identifier.orcid | Hutchison, A. [0000-0002-6393-3671] | - |
dc.identifier.orcid | Soenen, S. [0000-0002-0196-128X] | - |
dc.identifier.orcid | Clifton, [0000-0002-6411-626X] | - |
dc.identifier.orcid | Horowitz, [0000-0002-0942-0306] | - |
dc.identifier.orcid | Feinle-Bisset, [0000-0001-6848-0125] | - |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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hdl_101042.pdf | Published version | 896.84 kB | Adobe PDF | View/Open |
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