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https://hdl.handle.net/2440/102537
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Type: | Journal article |
Title: | The majority of murine γδ T cells at the maternal-fetal interface in pregnancy produce IL-17 |
Other Titles: | The majority of murine gamma delta T cells at the maternal-fetal interface in pregnancy produce IL-17 |
Author: | Pinget, G. Corpuz, T. Stolp, J. Lousberg, E. Diener, K. Robertson, S. Sprent, J. Webster, K. |
Citation: | Immunology and Cell Biology, 2016; 94(7):623-630 |
Publisher: | Nature Publishing Group |
Issue Date: | 2016 |
ISSN: | 0818-9641 1440-1711 |
Statement of Responsibility: | Gabriela V Pinget, Theresa M Corpuz, Jessica Stolp, Erin L Lousberg, Kerrilyn R Diener, Sarah A Robertson, Jonathan Sprent and Kylie E Webster |
Abstract: | Compared with lymphoid tissues, the immune cell compartment at mucosal sites is enriched with T cells bearing the γδ T-cell receptor (TCR). The female reproductive tract, along with the placenta and uterine decidua during pregnancy, are populated by γδ T cells predominantly expressing the invariant Vγ6(+)Vδ1(+) receptor. Surprisingly little is understood about the function of these cells. We found that the majority of γδ T cells in the non-pregnant uterus, pregnant uterus, decidua and placenta of mice express the transcription factor RORγt and produce interleukin-17 (IL-17). In contrast, IFNγ-producing γδ T cells were markedly reduced in gestational tissues compared with uterine-draining lymph nodes and spleen. Both uterine-resident invariant Vγ6(+) and Vγ4(+) γδ T cells which are more typically found in lymphoid tissues and circulating blood, were found to express IL-17. Vγ4(+) γδ T cells were particularly enriched in the placenta, suggesting a pregnancy-specific recruitment or expansion of these cells. A small increase in IL-17-producing γδ T cells was observed in allogeneic compared with syngeneic pregnancy, suggesting a contribution to regulating the maternal response to paternally-derived alloantigens. However, their high proportions also in non-pregnant uteri and gestational tissues of syngeneic pregnancy imply a role in the prevention of intrauterine infection or quality control of fetal development. These data suggest the need for a more rigorous evaluation of the role of IL-17 in sustaining normal pregnancy, particularly as emerging data points to a pathogenic role for IL-17 in pre-eclampsia, pre-term birth, miscarriage and maternal immune activation-induced behavioral abnormalities in offspring. |
Keywords: | Uterus T-Lymphocytes Placenta Animals Mice, Inbred C57BL Mice, Inbred DBA Receptors, Antigen, T-Cell, gamma-delta Interleukin-17 Pregnancy Maternal-Fetal Exchange Female Nuclear Receptor Subfamily 1, Group F, Member 3 |
Rights: | © 2016 Australasian Society for Immunology Inc. All rights reserved |
DOI: | 10.1038/icb.2016.48 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1045647 http://purl.org/au-research/grants/nhmrc/1045630 http://purl.org/au-research/grants/nhmrc/1016953 http://purl.org/au-research/grants/nhmrc/1020984 http://purl.org/au-research/grants/nhmrc/596805 http://purl.org/au-research/grants/nhmrc/1012386 |
Published version: | http://dx.doi.org/10.1038/icb.2016.48 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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