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https://hdl.handle.net/2440/104031
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Type: | Journal article |
Title: | n-3 fatty acid supplementation and leukocyte telomere length in patients with chronic kidney disease |
Author: | Barden, A. O Callaghan, N. Burke, V. Mas, E. Beilin, L.J. Fenech, M. Irish, A.B. Watts, G.F. Puddey, I.B. Huang, R.C. Mori, T.A. |
Citation: | Nutrients, 2016; 8(3):1-11 |
Publisher: | MDPI AG |
Issue Date: | 2016 |
ISSN: | 2072-6643 2072-6643 |
Statement of Responsibility: | Anne Barden, Nathan O'Callaghan, Valerie Burke, Emile Mas, Lawrence J. Beilin, Michael Fenech, Ashley B. Irish, Gerald F. Watts, Ian B. Puddey, Rae-Chi Huang and Trevor A. Mori |
Abstract: | DNA telomere shortening associates with the age-related increase cardiovascular disease (CVD) risk. Reducing oxidative stress, could modify telomere erosion during cell replication, and CVD risk in patients with chronic kidney disease (CKD). The effect of n-3 fatty acids and coenzyme Q10 (CoQ) on telomere length was studied in a double-blind placebo-controlled trial in CKD. Eighty-five CKD patients were randomized to: n-3 fatty acids (4 g); CoQ (200 mg); both supplements; or control (4 g olive oil), daily for 8 weeks. Telomere length was measured in neutrophils and peripheral blood mononuclear cells (PBMC) at baseline and 8 weeks, with and without correction for cell counts. Main and interactive effects of n-3 fatty acids and CoQ on telomere length were assessed adjusting for baseline values. F2-isoprostanes were measured as markers of oxidative stress. There was no effect of n-3 fatty acids or CoQ on neutrophil or PBMC telomere length. However, telomere length corrected for neutrophil count was increased after n-3 fatty acids (p = 0.015). Post-intervention plasma F2-isoprostanes were negative predictors of post-intervention telomere length corrected for neutrophil count (p = 0.025).The effect of n-3 fatty acids to increased telomere length corrected for neutrophil count may relate to reduced oxidative stress and increased clearance of neutrophils with shorter telomeres from the circulation. This may be a novel mechanism of modifying CVD risk in CKD patients. |
Keywords: | neutrophils; telomere length; oxidative stress; n-3 fatty acids; coenzyme Q10 |
Rights: | © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
DOI: | 10.3390/nu8030175 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/303151 http://purl.org/au-research/grants/nhmrc/1010495 |
Published version: | http://dx.doi.org/10.3390/nu8030175 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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hdl_104031.pdf | Published version | 577.88 kB | Adobe PDF | View/Open |
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