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https://hdl.handle.net/2440/104340
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Type: | Journal article |
Title: | Pro-survival role of protein kinase C epsilon in Philadelphia chromosome positive acute leukemia |
Author: | Loi, T. Dai, P. Carlin, S. Melo, J. Ma, D. |
Citation: | Leukemia and Lymphoma, 2016; 57(2):411-418 |
Publisher: | Taylor & Francis |
Issue Date: | 2016 |
ISSN: | 1042-8194 1029-2403 |
Statement of Responsibility: | To Ha Loi, Pei Dai, Stephen Carlin, Junia V. Melo and David D. F. Ma |
Abstract: | Durable responses to imatinib monotherapy are rarely seen in aggressive forms of Philadelphia chromosome positive (Ph+) leukemias. To investigate the possible cause of treatment failure we examined the role of protein kinase C epsilon (PKCE), an oncogene highly implicated in the development of solid tumors and resistance to chemotherapy. We found high levels of PKCE transcripts in Ph+ acute lymphoblastic leukemia (ALL) cells from patients and cell lines, and imatinib resistant chronic myeloid leukemia, which were also less responsive to imatinib-induced apoptosis than Ph+ cells with lower PKCE expression. Furthermore, the siRNA-mediated knockdown or peptide inhibition of PKCE in Ph+ cells increased imatinib-induced apoptosis while overexpression of PKCE reduced imatinib-induced apoptosis, with concomitant increase in the pro-survival factor AKT. Our results suggest PKCE plays a protective role against apoptosis induced by BCR-ABL inhibition in Ph+ leukemias with high PKCE expression, such as Ph+ ALL. |
Keywords: | BCR-ABL PKC epsilon imatinib resistance |
Rights: | © 2015 Informa UK, Ltd. |
DOI: | 10.3109/10428194.2015.1043545 |
Published version: | http://dx.doi.org/10.3109/10428194.2015.1043545 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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