Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/104688
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lane, J.M. | - |
dc.contributor.author | Liang, J. | - |
dc.contributor.author | Vlasac, I. | - |
dc.contributor.author | Anderson, S.G. | - |
dc.contributor.author | Bechtold, D.A. | - |
dc.contributor.author | Bowden, J. | - |
dc.contributor.author | Emsley, R. | - |
dc.contributor.author | Gill, S. | - |
dc.contributor.author | Little, M.A. | - |
dc.contributor.author | Luik, A.I. | - |
dc.contributor.author | Loudon, A. | - |
dc.contributor.author | Scheer, F.A.J.L. | - |
dc.contributor.author | Purcell, S.M. | - |
dc.contributor.author | Kyle, S.D. | - |
dc.contributor.author | Lawlor, D.A. | - |
dc.contributor.author | Zhu, X. | - |
dc.contributor.author | Redline, S. | - |
dc.contributor.author | Ray, D.W. | - |
dc.contributor.author | Rutter, M.K. | - |
dc.contributor.author | Saxena, R. | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Nature Genetics, 2017; 49(2):274-281 | - |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.issn | 1546-1718 | - |
dc.identifier.uri | http://hdl.handle.net/2440/104688 | - |
dc.description.abstract | Chronic sleep disturbances, associated with cardiometabolic diseases, psychiatric disorders and all-cause mortality¹’², affect 25–30% of adults worldwide³. Although environmental factors contribute substantially to self-reported habitual sleep duration and disruption, these traits are heritable⁴¯⁹ and identification of the genes involved should improve understanding of sleep, mechanisms linking sleep to disease and development of new therapies. We report single- and multiple-trait genome-wide association analyses of self-reported sleep duration, insomnia symptoms and excessive daytime sleepiness in the UK Biobank (n = 112,586). We discover loci associated with insomnia symptoms (near MEIS1, TMEM132E, CYCL1 and TGFBI in females and WDR27 in males), excessive daytime sleepiness (near AR–OPHN1) and a composite sleep trait (near PATJ (INADL) and HCRTR2) and replicate a locus associated with sleep duration (at PAX8). We also observe genetic correlation between longer sleep duration and schizophrenia risk (rg = 0.29, P = 1.90 × 10−¹³) and between increased levels of excessive daytime sleepiness and increased measures for adiposity traits (body mass index (BMI): rg = 0.20, P = 3.12 × 10⁻⁹; waist circumference: rg = 0.20, P = 2.12 × 10⁻⁷). | - |
dc.description.statementofresponsibility | Jacqueline M Lane, Jingjing Liang, Irma Vlasac, Simon G Anderson, David A Bechtold, Jack Bowden, Richard Emsley, Shubhroz Gill, Max A Little, Annemarie I Luik, Andrew Loudon, Frank A J L Scheer, Shaun M Purcell, Simon D Kyle, Deborah A Lawlor, Xiaofeng Zhu, Susan Redline, David W Ray, Martin K Rutter, Richa Saxena | - |
dc.language.iso | en | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.rights | © 2017 Nature America, Inc., part of Springer Nature. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1038/ng.3749 | - |
dc.subject | Behavioural genetics; genome-wide association studies | - |
dc.title | Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/ng.3749 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Lawlor, D.A. [0000-0002-6793-2262] | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.