Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/104783
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Type: | Journal article |
Title: | Cytokine-mediated blood brain barrier disruption as a conduit for cancer/chemotherapy-associated neurotoxicity and cognitive dysfunction |
Author: | Wardill, H. Mander, K. Van Sebille, Y. Gibson, R. Logan, R. Bowen, J. Sonis, S. |
Citation: | International Journal of Cancer, 2016; 139(12):2635-2645 |
Publisher: | Wliey |
Issue Date: | 2016 |
ISSN: | 0020-7136 1097-0215 |
Statement of Responsibility: | Hannah R. Wardill, Kimberley A. Mander, Ysabella Z.A. Van Sebille, Rachel J. Gibson, Richard M. Logan, Joanne M. Bowen, and Stephen T. Sonis |
Abstract: | Neurotoxicity is a common side effect of chemotherapy treatment, with unclear molecular mechanisms. Clinical studies suggest that the most frequent neurotoxic adverse events affect memory and learning, attention, concentration, processing speeds and executive function. Emerging preclinical research points toward direct cellular toxicity and induction of neuroinflammation as key drivers of neurotoxicity and subsequent cognitive impairment. Emerging data now show detectable levels of some chemotherapeutic agents within the CNS, indicating potential disruption of blood brain barrier integrity or transport mechanisms. Blood brain barrier disruption is a key aspect of many neurocognitive disorders, particularly those characterized by a proinflammatory state. Importantly, many proinflammatory mediators able to modulate the blood brain barrier are generated by tissues and organs that are targets for chemotherapy-associated toxicities. This review therefore aims to explore the hypothesis that peripherally derived inflammatory cytokines disrupt blood brain barrier permeability, thereby increasing direct access of chemotherapeutic agents into the CNS to facilitate neuroinflammation and central neurotoxicity. |
Keywords: | blood brain barrier chemotherapy-induced gut toxicity cognitive dysfunction inflammation neurotoxicity |
Rights: | © 2016 UICC |
DOI: | 10.1002/ijc.30252 |
Published version: | http://dx.doi.org/10.1002/ijc.30252 |
Appears in Collections: | Aurora harvest 7 Medicine publications |
Files in This Item:
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hdl_104783.pdf | Accepted version | 356.75 kB | Adobe PDF | View/Open |
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