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https://hdl.handle.net/2440/104933
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Type: | Journal article |
Title: | GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer |
Author: | Chen, M.M. O'Mara, T.A. Thompson, D.J. Painter, J.N. Attia, J. Black, A. Brinton, L. Chanock, S. Chen, C. Cheng, T.H. Cook, L.S. Crous-Bou, M. Doherty, J. Friedenreich, C.M. Garcia-Closas, M. Gaudet, M.M. Gorman, M. Haiman, C. Hankinson, S.E. Hartge, P. et al. |
Citation: | Human Molecular Genetics, 2016; 25(12):2612-2620 |
Publisher: | Oxford University Press |
Issue Date: | 2016 |
ISSN: | 0964-6906 1460-2083 |
Statement of Responsibility: | Maxine M. Chen, Tracy A. O'Mara, Deborah J. Thompson, Jodie N. Painter, John Attia … Joanne Young … et al. (The Australian National Endometrial Cancer Study Group and National Study Of Endometrial Cancer Genetics Group) |
Abstract: | Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10 -8) at 6p22.3 (rs1740828; P = 2.29 × 10 -8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer. |
Keywords: | Endometrial cancer; genetic predisposition to disease; genome; single nucleotide polymorphism; gynecologic cancer; genetic risk; genome-wide association study |
Rights: | © The Author 2016. Published by Oxford University Press. All rights reserved. |
DOI: | 10.1093/hmg/ddw092 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/339435 http://purl.org/au-research/grants/nhmrc/552402 http://purl.org/au-research/grants/nhmrc/1031333 |
Published version: | http://dx.doi.org/10.1093/hmg/ddw092 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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