Effect of “Garbha Cintamani Rasa”, an ayurvedic formulation on lipid profile, liver function and kidney function parameters of rat plasma after chronic administration

Abstract

Garbha Cintamani Rasa (GCM), a classical Ayurvedic preparation which is used in puerperal complications, was studied for its effect on liver function, kidney function and lipid profile after chronic administrations into the biological system. The experimental animal model was rat of both sexes. Triglycerides (TG) content was observed to be increased very high significantly in male as well as female group. Statistically, irrespective of sexes, high significant increase was found in very low density lipoprotein (VLDL). Decrease of total cholesterol (TC), low density lipoprotein (LDL) and high density lipoprotein (HDL) were negligible in male rats. Similar results were shown by female rats also. In both of the sexes, total protein and albumin content of plasma were increased very high significantly. In case of bilirubin, the increase was negligible for all sexes. The serum Effect of “Garbha Cintamani Rasa”, an Ayurvedic Formulation on Lipid Profile, Liver Function and Kidney Function Parameters of Rat Plasma after Chronic Administration. 26 glutamic pyruvic transaminase (sGPT), serum glutamic oxaloacetic transaminase (sGOT) and alkaline phosphatase (ALP) content in the plasma were decreased very high significantly in both of the experimental groups. Creatinine, urea and uric acid were decreased in male and female where only change of creatinine level was significant for both of the sexes. The changes of plasma parameters of both sexes were in similar fashion when one sex group is compared to opposite sex group.