Adelaide Research & Scholarship
Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/105133
| Citations | ||
| Scopus | Web of Science® | Altmetric |
|---|---|---|
|
?
|
?
|
|
| Type: | Journal article |
| Title: | Mechanism of bacterial interference with TLR4 signaling by brucella toll/interleukin-1 receptor domain-containing protein TcpB |
| Author: | Alaidarous, M. Ve, T. Casey, L. Valkov, E. Ericsson, D. Ullah, M. Schembri, M. Mansell, A. Sweet, M. Kobe, B. |
| Citation: | Journal of Biological Chemistry, 2014; 289(2):654-668 |
| Publisher: | American Society for Biochemistry and Molecular Biology Inc. |
| Issue Date: | 2014 |
| ISSN: | 0021-9258 1083-351X |
| Statement of Responsibility: | Mohammed Alaidarous, Thomas Ve, Lachlan W. Casey, Eugene Valkov, Daniel J. Ericsson, M. Obayed Ullah, Mark A. Schembri, Ashley Mansell, Matthew J. Sweet, and Bostjan Kobe |
| Abstract: | Background: TcpB is a TIR domain-containing protein form Brucella. Results: TcpB interacts with the host Toll-like receptor and adaptors, and its structure reveals a dimer essential for activity. Conclusion: TcpB forms a nonfunctional complex with host molecules, thus suppressing signaling. Significance: The work explains the structural and functional basis of immune suppression by the protein TcpB from a pathogenic bacterium. |
| Keywords: | Toll-Like Receptor 4; Myeloid Differentiation Factor 88 |
| Rights: | © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. |
| DOI: | 10.1074/jbc.M113.523274 |
| Grant ID: | http://purl.org/au-research/grants/nhmrc/1003326 http://purl.org/au-research/grants/arc/FT100100662 http://purl.org/au-research/grants/arc/FT100100657 http://purl.org/au-research/grants/nhmrc/1003470 http://purl.org/au-research/grants/nhmrc/1003325 |
| Published version: | http://dx.doi.org/10.1074/jbc.m113.523274 |
| Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 3 |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.