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https://hdl.handle.net/2440/106880
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Type: | Journal article |
Title: | Sentinel-lymph-node-based management or routine axillary clearance? five-year outcomes of the racs sentinel node biopsy versus axillary clearance (snac) 1 trial: assessment and incidence of true lymphedema |
Author: | Wetzig, N. Gill, P. Espinoza, D. Mister, R. Stockler, M. Gebski, V. Ung, O. Campbell, I. Simes, J. |
Citation: | Annals of Surgical Oncology, 2017; 24(4):1064-1070 |
Publisher: | Lippincott Williams & Wilkins |
Issue Date: | 2017 |
ISSN: | 1068-9265 1534-4681 |
Statement of Responsibility: | Neil Wetzig, Peter Grantley Gill, David Espinoza, Rebecca Mister, Martin R. Stockler, Val J. Gebski, Owen A. Ung, Ian Campbell, John Simes |
Abstract: | PURPOSE: To determine whether the benefits of sentinel-node-based management (SNBM) over routine axillary clearance (RAC) persisted to 5 years. METHODS: A total of 1088 women with breast cancer less than 3 cm in diameter and clinically negative axillary nodes were randomized to SNBM with axillary clearance if the sentinel node was positive or RAC preceded by sentinel-node biopsy. The outcomes were: (1) objectively measured change in the volume of the operated and contralateral nonoperated arms; (2) the proportion with an increase in arm volume <15%; and (3) subjectively assessed arm morbidity for the domains swelling, symptoms, dysfunction, and disability. Assessments were performed at 1 and 6 months after surgery and then annually. RESULTS: Limb volume increased progressively in the operated and nonoperated arms for 2 years and persisted unchanged to year 5, accompanied by weight gain. Correction by change in the nonoperated arm showed a mean volume increase of 70 mL in the RAC group and 26 mL in the SNBM group (P < 0.001) at 5 years. Only 28 patients (3.3%) had a corrected increase >15% from baseline (RAC 5.0% vs. SNBM 1.7%). Significant predictors were surgery type (RAC vs. SNBM), obesity, diabetes, palpable tumor, and weight gain exceeding 10% of baseline value. CONCLUSIONS: Subjective assessments revealed persisting patient concerns about swelling and symptoms but not overall disability at 5 years. Subjective scores were only moderately correlated with volume increase. SNAC1 has demonstrated that objective morbidity and subjective morbidity persist for 5 years after surgery and that SNBM significantly lowers the risk of both. |
Keywords: | Upper Extremity Axilla Humans Breast Neoplasms Lymphedema Chronic Disease Weight Gain Sentinel Lymph Node Biopsy Disability Evaluation Organ Size Lymph Node Excision Tumor Burden Follow-Up Studies Time Factors Female Sentinel Lymph Node |
Rights: | © Society of Surgical Oncology 2016 |
DOI: | 10.1245/s10434-016-5669-2 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1046018 http://purl.org/au-research/grants/nhmrc/512378 http://purl.org/au-research/grants/nhmrc/1037786 |
Published version: | http://dx.doi.org/10.1245/s10434-016-5669-2 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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