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https://hdl.handle.net/2440/110917
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Type: | Journal article |
Title: | Ibudilast reduces oxaliplatin-induced tactile allodynia and cognitive impairments in rats |
Author: | Johnston, I. Tan, M. Cao, J. Matsos, A. Forrest, D. Si, E. Fardell, J. Hutchinson, M. |
Citation: | Behavioural Brain Research, 2017; 334:109-118 |
Publisher: | Elsevier |
Issue Date: | 2017 |
ISSN: | 0166-4328 1872-7549 |
Statement of Responsibility: | Ian N. Johnstona, Manuela Tana, Jacob Caoa, Antigone Matsosa, Daniel R.L. Forresta, Emily Sia, Joanna E. Fardella, Mark R. Hutchinsonc |
Abstract: | Chemotherapy can cause serious neurotoxic side effects, such as painful peripheral neuropathies and disabling cognitive impairments. Four experiments examined whether Ibudilast, a clinically approved neuroimmune therapy, would reduce tactile allodynia and memory impairments caused by oxaliplatin in laboratory rats. Rats received an intraperitoneal injection of oxaliplatin (6mg/kg i.p.) or vehicle and were assessed for tactile allodynia 3 or 5days after injection, memory impairments in the novel object and novel location recognition tests 10-12days after injection, and fear conditioning 14days after injection. Ibudilast (7.5mg/kg) or vehicle was administered prior to oxaliplatin (Experiments 1 and 3) or prior to behavioural testing (Experiments 2 and 4). Ibudilast treatment prior to oxaliplatin prevented the development of tactile allodynia and memory impairments. Ibudilast treatment prior to behavioural testing reduced oxaliplatin-induced tactile allodynia, memory impairments, and impaired renewal of fear conditioning. These results suggest that Ibudilast could be an effective treatment against oxaliplatin-induced neuropathies and cognitive impairments. |
Keywords: | Oxaliplatin; chemotherapy; neuropathic pain; memory impairment; ibudilast |
Rights: | © 2017 Elsevier B.V. All rights reserved. |
DOI: | 10.1016/j.bbr.2017.07.021 |
Grant ID: | http://purl.org/au-research/grants/arc/DP110100297 |
Published version: | http://dx.doi.org/10.1016/j.bbr.2017.07.021 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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