Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/111810
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Type: | Journal article |
Title: | Pain-causing venom peptides: insights into sensory neuron pharmacology |
Author: | Jami, S. Erickson, A. Brierley, S. Vetter, I. |
Citation: | Toxins, 2018; 10(1):1-15 |
Publisher: | MDPI |
Issue Date: | 2018 |
ISSN: | 2072-6651 2072-6651 |
Statement of Responsibility: | Sina Jami, Andelain Erickson, Stuart M. Brierley and Irina Vetter |
Abstract: | Venoms are produced by a wide variety of species including spiders, scorpions, reptiles, cnidarians, and fish for the purpose of harming or incapacitating predators or prey. While some venoms are of relatively simple composition, many contain hundreds to thousands of individual components with distinct pharmacological activity. Pain-inducing or "algesic" venom compounds have proven invaluable to our understanding of how physiological nociceptive neural networks operate. In this review, we present an overview of some of the diverse nociceptive pathways that can be modulated by specific venom components to evoke pain. |
Keywords: | ASIC TRP channel animal venom pain pore forming toxin sodium channel |
Rights: | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
DOI: | 10.3390/toxins10010015 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1126378 http://purl.org/au-research/grants/nhmrc/1083480 http://purl.org/au-research/grants/nhmrc/1139366 http://purl.org/au-research/grants/nhmrc/1102267 http://purl.org/au-research/grants/nhmrc/1125766 http://purl.org/au-research/grants/nhmrc/1140297 http://purl.org/au-research/grants/arc/FT130101215 |
Published version: | http://dx.doi.org/10.3390/toxins10010015 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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hdl_111810.pdf | Published version | 766.22 kB | Adobe PDF | View/Open |
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