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https://hdl.handle.net/2440/113252
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Type: | Journal article |
Title: | Polyandric acid A, a clerodane diterpenoid from the Australian medicinal plant Dodonaea polyandra, attenuates pro-inflammatory cytokine secretion in vitro and in vivo |
Author: | Simpson, B. Luo, X. Costabile, M. Caughey, G. Wang, J. Claudie, D. McKinnon, R. Semple, S. |
Citation: | Journal of Natural Products, 2014; 77(1):85-91 |
Publisher: | American Chemical Society |
Issue Date: | 2014 |
ISSN: | 0163-3864 1520-6025 |
Statement of Responsibility: | Bradley S. Simpson, Xianling Luo, Maurizio Costabile, Gillian E. Caughey, Jiping Wang, David J. Claudie, Ross A. McKinnon, and Susan J. Semple |
Abstract: | Dodonaea polyandra is a medicinal plant used traditionally by the Kuuku I'yu (Northern Kaanju) indigenous people of Cape York Peninsula, Australia. The most potent of the diterpenoids previously identified from this plant, polyandric acid A (1), has been examined for inhibition of pro-inflammatory cytokine production and other inflammatory mediators using well-established acute and chronic mouse ear edema models and in vitro cellular models. Topical application of 1 significantly inhibited interleukin-1β production in mouse ear tissue in an acute model. In a chronic skin inflammation model, a marked reduction in ear thickness, associated with significant reduction in myeloperoxidase accumulation, was observed. Treatment of primary neonatal human keratinocytes with 1 followed by activation with phorbol ester/ionomycin showed a significant reduction in IL-6 secretion. The present study provides evidence that the anti-inflammatory properties of 1 are due to inhibition of pro-inflammatory cytokines associated with skin inflammation and may be useful in applications for skin inflammatory conditions including psoriasis and dermatitis. |
Keywords: | Macrophages |
Description: | Published: January 8, 2014 |
Rights: | © 2014 American Chemical Society and American Society of Pharmacognosy |
DOI: | 10.1021/np400704b |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1017556 |
Published version: | http://dx.doi.org/10.1021/np400704b |
Appears in Collections: | Aurora harvest 3 Pharmacology publications |
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