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https://hdl.handle.net/2440/113410
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dc.contributor.author | Swaminathan, A. | - |
dc.contributor.author | Lucas, R.M. | - |
dc.contributor.author | Dear, K. | - |
dc.contributor.author | McMichael, A.J. | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | British Journal of Clinical Pharmacology, 2014; 78(5):1135-1142 | - |
dc.identifier.issn | 0306-5251 | - |
dc.identifier.issn | 1365-2125 | - |
dc.identifier.uri | http://hdl.handle.net/2440/113410 | - |
dc.description.abstract | Immunization with a T-cell dependent antigen has been promoted as a reliable and sensitive tool for assessing the influence of putative immunotoxic exposures or agents on immune function. Keyhole limpet haemocyanin (KLH) is a very large, copper-containing protein molecule derived from the haemolymph of the inedible mollusc, Megathura crenulata. KLH is a highly immunogenic T-cell dependent antigen that is used increasingly in immunotoxicological studies, particularly in those involving animals. This report systematically reviews the human clinical studies that have used trans-cutaneous KLH immunization for assessment of the influence of various physiological and disease states and exposures on immune function over the last 20 years (1994-2013). These studies varied in their immunization protocols, formulation of KLH, dose, site and route of administration and immunoassay platforms developed to assess KLH-specific responses. KLH immunization has been well tolerated with only mild to moderate adverse effects reported. Though very promising as a model antigen candidate in immunotoxicology research, more work on standardizing immunization and immunoassay protocols is required. | - |
dc.description.statementofresponsibility | Ashwin Swaminathan, Robyn M. Lucas, Keith Dear & Anthony J. McMichael | - |
dc.language.iso | en | - |
dc.publisher | British Pharmacological Society Journals | - |
dc.rights | © 2014 The British Pharmacological Society | - |
dc.source.uri | http://dx.doi.org/10.1111/bcp.12422 | - |
dc.subject | Clinical studies | - |
dc.subject | Immunization | - |
dc.subject | Immunotoxicology | - |
dc.subject | Keyhole limpet haemocyanin | - |
dc.subject | KLH | - |
dc.title | Keyhole limpet haemocyanin - A model antigen for human immunotoxicological studies | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/bcp.12422 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/585489 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Dear, K. [0000-0002-0788-7404] | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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