Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/115985
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Type: | Journal article |
Title: | Effect of low dose docosahexaenoic acid-rich fish oil on plasma lipids and lipoproteins in pre-menopausal women: a dose-response randomized placebo-controlled trial |
Author: | Sparkes, C. Gibson, R. Sinclair, A. Else, P. Meyer, B. |
Citation: | Nutrients, 2018; 10(10):1460-1-1460-17 |
Publisher: | MDPI AG |
Issue Date: | 2018 |
ISSN: | 2072-6643 2072-6643 |
Statement of Responsibility: | Cassandra Sparkes, Robert Gibson, Andrew Sinclair, Paul L. Else and Barbara J. Meyer |
Abstract: | Omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation has been shown to improve plasma lipid profiles in men and post-menopausal women, however, data for pre-menopausal women are lacking. The benefits of intakes less than 1 g/day have not been well studied, and dose⁻response data is limited. The aim of this study was to determine the effect of low doses of docosahexaenoic acid (DHA)-rich tuna oil on plasma triglyceride (TG) lowering in pre-menopausal women, and investigate if low dose DHA-rich tuna oil supplementation would increase the low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle sizes. A randomized, double-blind, placebo-controlled trial was conducted, in which 53 healthy pre-menopausal women with mildly elevated plasma TG levels consumed 0, 0.35, 0.7, or 1 g/day n-3 LCPUFA as HiDHA™ tuna oil or placebo (Sunola oil) capsules for 8 weeks. Supplementation with 1 g/day n-3 LCPUFA, but not lower doses, reduced plasma TG by 23% in pre-menopausal women. This was reflected in a dose-dependent reduction in very-low-density lipoprotein (VLDL)-TG (R² = 0.20, p = 0.003). A weak dose-dependent shift in HDL (but not LDL) particle size was identified (R² = 0.05, p = 0.04). The results of this study indicate that DHA-rich n-3 LCPUFA supplementation at a dose of 1 g/day is an effective TG-lowering agent and increases HDL particle size in pre-menopausal women. |
Keywords: | DHA plasma lipids lipoproteins premenopausal women |
Description: | Published: 8 October 2018 |
Rights: | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
DOI: | 10.3390/nu10101460 |
Grant ID: | http://purl.org/au-research/grants/arc/LP0562017 |
Published version: | http://dx.doi.org/10.3390/nu10101460 |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 8 |
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hdl_115985.pdf | Published version | 646.23 kB | Adobe PDF | View/Open |
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