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https://hdl.handle.net/2440/11706
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Type: | Journal article |
Title: | Chronic effect of insulin-like growth factor I on renin synthesis, secretion, and renal function in fetal sheep |
Author: | Marsh, A. Gibson, K. Wu, J. Owens, P. Owens, J. Lumbers, E. |
Citation: | American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 2001; 281(1):R318-R326 |
Publisher: | American Physiological Society |
Issue Date: | 2001 |
ISSN: | 0363-6119 1522-1490 |
Statement of Responsibility: | Amanda C. Marsh, Karen J. Gibson, June Wu, Phillip C. Owens, Julie A. Owens and Eugenie R. Lumbers |
Abstract: | In the adult, insulin-like growth factor I (IGF-I) increases glomerular filtration rate (GFR) and renal blood flow (RBF) during both acute and chronic treatment. To study its effects on the developing kidney, chronically catheterized fetal sheep (120 ± 1 days gestation) were infused intravenously for up to 10 days with 80 µg/h IGF-I (n = 5) or vehicle (0.1% BSA in saline, n = 6). In contrast to previous acute studies in adult rats and humans, after 4 h of IGF-I fetal GFR and RBF were unchanged. Fractional sodium reabsorption increased (P < 0.05). However, by 4 days, GFR per kilogram had risen by 35 ± 13% (P < 0.05), whereas RBF remained unchanged. Tubular growth and maturation may have occurred, as proximal tubular sodium reabsorption increased by ~35% (P < 0.005). Therefore, despite a marked increase in filtered sodium (~30%, P < 0.05), fractional sodium reabsorption did not change. Although the effects of IGF-I on renal function were delayed, plasma renin activity and concentration were both elevated after 4 h and remained high at 4 days (P < 0.05). Despite this, arterial pressure and heart rate did not change. Kidneys of IGF-I-infused fetuses weighed ~30% more (P = 0.05) and contained ~75% more renin than control fetuses (P < 0.005). Thus, in the fetus, the renal effects of long-term IGF-I infusion are very different from the adult, possibly because IGF-I stimulated kidney growth. |
Keywords: | Kidney development renin-angiotensin system glomerular filtration |
Rights: | Copyright © 2001 by the American Physiological Society |
DOI: | 10.1152/ajpregu.2001.281.1.r318 |
Published version: | http://ajpregu.physiology.org/content/281/1/R318 |
Appears in Collections: | Aurora harvest 2 Physiology publications |
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