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https://hdl.handle.net/2440/117073
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Type: | Journal article |
Title: | Historical evolution of ideas on eclampsia/preeclampsia: a proposed optimistic view of preeclampsia |
Author: | Robillard, P.-Y. Dekker, G. Chaouat, G. Scioscia, M. Iacobelli, S. Hulsey, T.C. |
Citation: | Journal of Reproductive Immunology, 2017; 123:72-77 |
Publisher: | Elsevier |
Issue Date: | 2017 |
ISSN: | 0165-0378 1872-7603 |
Statement of Responsibility: | Pierre-Yves Robillard, Gustaaf Dekker, Gérard Chaouat, Marco Scioscia, Silvia Iacobelli, Thomas C. Hulsey |
Abstract: | Eclampsia (together with epilepsy) being the first disease ever written down since the beginning of writings in mankind 5000 years ago, we will make a brief presentation of the different major steps in comprehension of Pre-eclampsia. 1) 1840. Rayer, description of proteinuria in eclampsia, 2) 1897 Vaquez, discovery of gestational hypertension in eclamptic women, 3) In the 1970's, description of the "double" trophoblastic invasion existing only in humans (Brosens & Pijnenborg,), 4) between the 1970's and the 1990's, description of preeclampsia being a couple disease. The "paternity problem" (and therefore irruption of immunology), 5) at the end of the 1980's, a major step forward: Preeclampsia being a global endothelial cell disease (glomeruloendotheliosis, hepatic or cerebral endotheliosis, HELLP, eclampsia), inflammation (J.Roberts.C Redman, R Taylor), 6) End of the 1990's: Consensus for a distinction between early onset preeclampsia EOP and late onset LOP (34 weeks gestation), EOP being rather a problem of implantation of the trophoblast (and the placenta), LOP being rather a pre-existing maternal problem (obesity, diabetes, coagulopathies etc…). LOP is predominant everywhere on this planet, but enormously predominant in developed countries: 90% of cases. This feature is very different in countries where women have their first child very young (88% of world births), where the fatal EOP (early onset) occurs in more than 30% of cases. 7) What could be the common factor which could explain the maternal global endotheliosis in EOP and LOP? Discussion about the inositol phospho glycans P type. |
Keywords: | Preeclampsia; immunology |
Rights: | © 2017 Published by Elsevier Ireland Ltd. |
DOI: | 10.1016/j.jri.2017.09.006 |
Published version: | http://dx.doi.org/10.1016/j.jri.2017.09.006 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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