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https://hdl.handle.net/2440/117187
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dc.contributor.author | Zhou, C. | - |
dc.contributor.author | Yool, A. | - |
dc.contributor.author | Byard, R. | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Journal of Forensic Sciences, 2017; 62(3):681-685 | - |
dc.identifier.issn | 0022-1198 | - |
dc.identifier.issn | 1556-4029 | - |
dc.identifier.uri | http://hdl.handle.net/2440/117187 | - |
dc.description.abstract | Basal vacuolization of renal tubular epithelial cells is a useful postmortem marker for ketoacidosis. To investigate its incidence and relationship to the severity of ketoacidosis, 158 autopsy cases with elevated β-hydroxybutyrate (>1 mmol/L) over a 7-year-period were retrospectively reviewed. Sixty-eight cases (43%) exhibited basal vacuolizations (vitreous β-hydroxybutyrate: 1.16-29.35 mmol/L, mean 10.28 mmol/L), and 90 cases (57%) did not (vitreous β-hydroxybutyrate: 1.03-13.7 mmol/L, mean 2.84 mmol/L). Quantitative analysis revealed on average a fourfold elevation in β-hydroxybutyrate in cases with basal vacuolizations compared to those without; 10.3% of cases with β-hydroxybutyrate concentrations between 1.01 and 2.00 mmol/L had basal vacuolizations, and this incidence increased to 33.3% with concentrations between 4.01 and 6.00 mmol/L. A marked increase in incidence to >70% was observed with concentrations >6.00 mmol/L, and basal vacuoles were invariably present (100%) with concentrations >14.01 mmol/L. This study demonstrates that basal vacuolizations are a sensitive marker for significant ketoacidosis and reaffirms its use as an indicator for likely cases of fatal ketoacidosis at autopsy. | - |
dc.description.statementofresponsibility | Chong Zhou, Andrea J. Yool and Roger W. Byard | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.rights | © 2017 American Academy of Forensic Sciences | - |
dc.source.uri | http://dx.doi.org/10.1111/1556-4029.13311 | - |
dc.subject | Forensic science; basal vacuolization; diabetic ketoacidosis; starvation ketoacidosis; alcoholic ketoacidosis; septic ketoacidosis; diabetes mellitus | - |
dc.title | Basal vacuolization in renal tubular epithelial cells at autopsy and their relation to ketoacidosis | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/1556-4029.13311 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Yool, A. [0000-0003-1283-585X] | - |
dc.identifier.orcid | Byard, R. [0000-0002-0524-5942] | - |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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