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https://hdl.handle.net/2440/117530
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Type: | Journal article |
Title: | Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic |
Author: | Morrison, J. Botting, K. Darby, J. David, A. Dyson, R. Gatford, K. Gray, C. Herrera, E. Hirst, J. Kim, B. Kind, K. Krause, B. Matthews, S. Palliser, H. Regnault, T. Richardson, B. Sasaki, A. Thompson, L. Berry, M. |
Citation: | The Journal of Physiology, 2018; 596(23):5535-5569 |
Publisher: | Wiley |
Issue Date: | 2018 |
ISSN: | 0022-3751 1469-7793 |
Statement of Responsibility: | Janna L. Morrison, Kimberley J. Botting, Jack R.T. Darby, Anna L. David, Rebecca M. Dyson, Kathryn L. Gatford, Clint Gray, Emilio A. Herrera, Jonathan J. Hirst, Bona Kim, Karen L. Kind, Bernardo J. Krause, Stephen G. Matthews, Hannah K. Palliser, Timothy R.H. Regnault, Bryan S. Richardson, Aya Sasaki, Loren P. Thompson and Mary J. Berry |
Abstract: | Over 30 years ago Sir David Barker first proposed the theory that events in early life could explain an individuals' risk of non-communicable disease in later life; the Developmental Origins of Health and Disease (DOHaD) theory. During the 1990s the validity of the DOHaD theory was extensively tested in a number of human populations and the mechanisms underpinning it characterised in a range of experimental animal models. Over the past decade, researchers have sought to use this mechanistic understanding of DOHaD to develop therapeutic interventions during pregnancy and early life to improve adult health. A variety of animal models have been used to develop and evaluate interventions, each with strengths and limitations. It is becoming apparent that effective translational research requires that the animal paradigm selected mirrors the tempo of human fetal growth and development as closely as possible so that the effect of a perinatal insult and/or therapeutic intervention can be fully assessed. The guinea pig is one such animal model that over the past two decades has demonstrated itself to be a very useful platform for these important reproductive studies. This review highlights similarities in the in utero development between humans and guinea pigs, their strengths and limitations as an experimental model of DOHaD and their potential to enhance clinical therapeutic innovation to improve human health. |
Keywords: | DOHaD; guinea pig; animal models; fetus; placenta; pregnancy |
Rights: | © 2018 The Authors. The Journal of Physiology © 2018 The Physiological Society |
DOI: | 10.1113/jp274948 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1066916 |
Published version: | http://dx.doi.org/10.1113/jp274948 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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