An integrated platform for capture of circulating tumor cells and in situ SERS profiling of membrane proteins through rational spatial organization of multi-functional cyclic RGD nanopatterns

Abstract

It is significant to in situ monitor membrane proteins at the singlecell level for understanding the cell function. Herein, an integrated platform was designed and constructed for highly efficient cell capture and in situ sensitive SERS determination of HER2 activity in cells through rational spatial organization of multi-functional cyclic RGD nanopatterns at a disordered mesoporous gold film via electrochemical activation.