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https://hdl.handle.net/2440/119742
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Type: | Journal article |
Title: | Immunolocalization of apolipoprotein d, androgen receptor and prostate specific antigen in early stage prostate cancers |
Author: | Zhang, S.X.D. Bentel, J.M. Ricciardelli, C. Horsfall, D.J. Haagensen, D.E. Marshall, V.R. Tilley, W.D. |
Citation: | The Journal of Urology, 1998; 159(2):548-554 |
Publisher: | Elsevier |
Issue Date: | 1998 |
ISSN: | 0022-5347 1527-3792 |
Statement of Responsibility: | Steven X.D. Zhang, Jacqueline M. Bentel, Carmela Ricciardelli, David J. Horsfall, Darrow E. Haagensen, Villis R. Marshall and Wayne D. Tilley |
Abstract: | PURPOSE: To determine the cellular distribution and levels of immunohistochemical staining for apolipoprotein D (Apo-D), prostate specific antigen (PSA) and androgen receptor (AR) in early stage prostate cancers. MATERIALS AND METHODS: Cellular distribution of Apo-D, PSA and AR in 30 stage A/B prostate cancers and in non-malignant glandular tissue contained in the same sections was detected immunohistochemically, and staining was evaluated by computerized video image analysis. RESULTS: Staining for Apo-D (percentage positive cellular area) was significantly increased in tumor cells of early stage prostate cancers compared with non-malignant glandular tissue. PSA and AR were present at high levels in both early stage prostate tumors and non-malignant prostate. CONCLUSIONS: Malignant transformation in the prostate is associated with increased cellular levels of Apo-D. |
Keywords: | Apolipoproteins D |
Rights: | © 1998 by American Urological Association, Inc. |
DOI: | 10.1016/S0022-5347(01)63981-8 |
Published version: | http://dx.doi.org/10.1016/s0022-5347(01)63981-8 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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