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https://hdl.handle.net/2440/120147
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Type: | Journal article |
Title: | Defining primary systemic sclerosis heart involvement: a scoping literature review |
Author: | Ross, L. Prior, D. Proudman, S. Vacca, A. Baron, M. Nikpour, M. |
Citation: | Seminars in Arthritis and Rheumatism, 2019; 48(5):874-887 |
Publisher: | Elsevier |
Issue Date: | 2019 |
ISSN: | 0049-0172 1532-866X |
Statement of Responsibility: | Laura Ross, David Prior, Susanna Proudman, Alessandra Vacca, Murray Baron, Mandana Nikpour |
Abstract: | BACKGROUND:Clinically evident primary heart involvement due to systemic sclerosis (SHI) is considered a poor prognostic factor and is a leading cause of systemic sclerosis (SSc) related death. Yet, there remains no consensus definition of SHI and poor understanding of the natural history and risk factors for the development of SHI. METHODS:We performed a scoping literature review of published articles with a primary focus of SHI to capture previously used definitions of SHI and items used to measure SHI. Any factors reported to be associated with an increased risk of SHI were recorded. RESULTS:Of the 2436 records identified in a search of MEDLINE, EMBASE and PubMed databases, 295 were included in the final scoping review. Analysis of the literature revealed studies of variable quality, generally low patient numbers and highly heterogeneous definitions of SHI within studies. There is no clear consensus from the literature as to the scope of SHI and the prognostic significance of sub-clinical investigation abnormalities commonly detected. CONCLUSION:The lack of a standardised definition of SHI remains a significant unmet need in SSc. The results of this review will assist in the development of consensus classification criteria to enable more accurate quantification of the burden of SHI, identification of factors associated with increased risk of developing SHI, and evaluation of the efficacy of any novel therapeutic strategies. |
Keywords: | Cardiac disease Definition Myocardial disease Scleroderma Scoping review Systemic sclerosis |
Rights: | © 2018 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.semarthrit.2018.07.008 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1126370 |
Published version: | http://dx.doi.org/10.1016/j.semarthrit.2018.07.008 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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