Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/121221
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Type: | Journal article |
Title: | Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases |
Author: | Guerreiro, R. Escott-Price, V. Darwent, L. Parkkinen, L. Ansorge, O. Hernandez, D.G. Nalls, M.A. Clark, L. Honig, L. Marder, K. van der Flier, W. Holstege, H. Louwersheimer, E. Lemstra, A. Scheltens, P. Rogaeva, E. St George-Hyslop, P. Londos, E. Zetterberg, H. Ortega-Cubero, S. et al. |
Citation: | Neurobiology of Aging, 2016; 38:214.e7-1-214.e7-4 |
Publisher: | Elsevier |
Issue Date: | 2016 |
ISSN: | 0197-4580 1558-1497 |
Statement of Responsibility: | Rita Guerreiro, Valentina Escott-Price, Lee Darwent, Laura Parkkinen, Olaf Ansorge ... Tamas Revesz ... et al. |
Abstract: | The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. |
Keywords: | Dementia with Lewy bodies; Alzheimer's disease; Parkinson's disease; genetic correlation |
Rights: | © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).http://dx.doi.org/10.1016/j.neurobiolaging.2015.10.028 |
DOI: | 10.1016/j.neurobiolaging.2015.10.028 |
Published version: | http://dx.doi.org/10.1016/j.neurobiolaging.2015.10.028 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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hdl_121221.pdf | Published version | 184.67 kB | Adobe PDF | View/Open |
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