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https://hdl.handle.net/2440/125
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Type: | Journal article |
Title: | A Drosophila salivary gland mucin is also expressed in immune tissues: evidence for a function in coagulation and the entrapment of bacteria |
Author: | Korayem, A. Fabbri, M. Takahashi, K. Scherfer, C. Lindgren, M. Schmidt, O. Ueda, R. Dushay, M. Theopold, U. |
Citation: | Insect Biochemistry and Molecular Biology, 2004; 34(12):1297-1304 |
Publisher: | Pergamon-Elsevier Science Ltd |
Issue Date: | 2004 |
ISSN: | 0965-1748 |
Statement of Responsibility: | Ahmed M. Korayem, Marco Fabbri, Kuniaki Takahashi, Christoph Scherfer, Malin Lindgren, Otto Schmidt, Ryu Ueda, Mitchell S. Dushay and Ulrich Theopold |
Abstract: | Our studies on the developmental regulation of glycosylation in Drosophila melanogaster led us to identify and characterize gp150, an ecdysone-regulated mucin that is found in hemocytes, the gut (peritrophic membrane) and in the salivary glands. We are particularly interested in mucin immune functions and found that gp150 is released from larval hemocytes, becomes part of the clot and participates in the entrapment of bacteria. By RT-PCR and RNAi experiments, we identified gp150 as the previously described I71-7, an ecdysone-induced salivary glue protein. We discuss the evolutionary and biochemical implications of the dual use of salivary proteins for immune functions in insects. Further molecular characterization of such shared proteins may enable a better understanding of the properties of proteins involved in containment and elimination of microbes, as well as hemostasis and wound repair. |
Keywords: | Mucin innate immunity o-glycosylation salivary glands hemolymph insect immunity coagulation hemocytes peritrophic membrane RNAi |
DOI: | 10.1016/j.ibmb.2004.09.001 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/390/description#description |
Published version: | http://dx.doi.org/10.1016/j.ibmb.2004.09.001 |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 6 |
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