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https://hdl.handle.net/2440/128772
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dc.contributor.author | Zhang, J. | - |
dc.contributor.author | Yun, S. | - |
dc.contributor.author | Du, Y. | - |
dc.contributor.author | Zannettino, A. | - |
dc.contributor.author | Zhang, H. | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Applied Materials Today, 2020; 20:100747-1-100747-19 | - |
dc.identifier.issn | 2352-9407 | - |
dc.identifier.issn | 2352-9407 | - |
dc.identifier.uri | http://hdl.handle.net/2440/128772 | - |
dc.description.abstract | Cell aggregates are widely used either as in-vitro models for drug screening, fundamental studies on disease progression and developmental biology, as well as in-vivo injectable cells for tissue regeneration. Compared to single-cell suspensions, cell aggregates retain superior cell viability, mimic in-vivo microenvironments and enhance functional properties, such as superior anti-inflammatory properties of mesenchymal stem/stromal cell aggregates or enhanced albumin production by hepatocyte aggregates. Cell aggregates can be either prepared by conventional spontaneous aggregation, or advanced substrate-based and technology-assisted methods, which have been well described in previous reviews. However, hydrogel-based preparation of cell aggregates is a novel, hitherto rarely considered method compared to conventional preparation of cell aggregates, such as hanging drops and commercial AggreWell™ plates. This review will mainly focus on two-dimensional (2D) hydrogel surface -based and three-dimensional (3D) hydrogel embedding-based preparation of cell aggregates by revealing the underlying mechanisms and highlighting some of their potential biomedical applications. | - |
dc.description.statementofresponsibility | Jiabin Zhang, Seonho Yun, Yuguang Du, Andrew Zannettino, Hu Zhang | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 2020 Elsevier Ltd. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.apmt.2020.100747 | - |
dc.subject | 2D; 3D; hydrogel; cell aggregate; biomedical application | - |
dc.title | Hydrogel-based preparation of cell aggregates for biomedical applications | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.apmt.2020.100747 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP160104632 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Zannettino, A. [0000-0002-6646-6167] | - |
dc.identifier.orcid | Zhang, H. [0000-0003-4178-6401] | - |
Appears in Collections: | Aurora harvest 8 Chemical Engineering publications |
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