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https://hdl.handle.net/2440/129433
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Type: | Journal article |
Title: | Aerobic C-H olefination of indoles via a cross-dehydrogenative coupling in continuous flow |
Author: | Gemoets, H.P.L. Hessel, V. Noël, T. |
Citation: | Organic Letters, 2014; 16(21):5800-5803 |
Publisher: | American Chemical Society |
Issue Date: | 2014 |
ISSN: | 1523-7060 1523-7052 |
Statement of Responsibility: | Hannes P. L. Gemoets, Volker Hessel, and Timothy Noël |
Abstract: | Herein, we report the first site-selective, Pd(II)-catalyzed, cross-dehydrogenative Heck reaction of indoles in micro flow. By use of a capillary microreactor, we were able to boost the intrinsic kinetics to accelerate former hour-scale reaction conditions in batch to the minute range in flow. The synergistic use of microreactor technology and oxygen, as both terminal oxidant and mixing motif, highlights the sustainable aspect of this process. |
Keywords: | Oxygen Palladium Alkenes Indoles Oxidants Molecular Structure Kinetics Catalysis Hydrogen Bonding |
Rights: | © 2014 American Chemical Society |
DOI: | 10.1021/ol502910e |
Grant ID: | ECHO 713.013.001 VENI 12464 |
Published version: | http://dx.doi.org/10.1021/ol502910e |
Appears in Collections: | Aurora harvest 4 Chemistry publications |
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