Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/129660
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Gastrointestinal mechanisms underlying the cardiovascular effect of metformin |
Author: | Borg, M.J. Rayner, C.K. Jones, K.L. Horowitz, M. Xie, C. Wu, T. |
Citation: | Pharmaceuticals, 2020; 13(11):1-14 |
Publisher: | MDPI |
Issue Date: | 2020 |
ISSN: | 1424-8247 1424-8247 |
Statement of Responsibility: | Malcolm J. Borg, Christopher K. Rayner, Karen L. Jones, Michael Horowitz, Cong Xie and Tongzhi Wu |
Abstract: | Metformin, the most widely prescribed drug therapy for type 2 diabetes, has pleiotropic benefits, in addition to its capacity to lower elevated blood glucose levels, including mitigation of cardiovascular risk. The mechanisms underlying the latter remain unclear. Mechanistic studies have, hitherto, focused on the direct effects of metformin on the heart and vasculature. It is now appreciated that effects in the gastrointestinal tract are important to glucose-lowering by metformin. Gastrointestinal actions of metformin also have major implications for cardiovascular function. This review summarizes the gastrointestinal mechanisms underlying the action of metformin and their potential relevance to cardiovascular benefits. |
Keywords: | Metformin; cardiovascular; gastrointestinal; mechanisms; bile acids; gut microbiota; glucagon-like-peptide-1; gastric emptying; postprandial hypotension; type 2 diabetes |
Rights: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
DOI: | 10.3390/ph13110410 |
Published version: | http://dx.doi.org/10.3390/ph13110410 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.