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https://hdl.handle.net/2440/129858
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Type: | Journal article |
Title: | Role of intestinal glucose absorption in glucose tolerance |
Author: | Wu, T. Rayner, C.K. Jones, K.L. Xie, C. Marathe, C. Horowitz, M. |
Citation: | Current Opinion in Pharmacology, 2020; 55:116-124 |
Publisher: | Elsevier |
Issue Date: | 2020 |
ISSN: | 1471-4892 1471-4973 |
Statement of Responsibility: | Tongzhi Wu, Christopher K Rayner, Karen L Jones, Cong Xie, Chinmay Marathe and Michael Horowitz |
Abstract: | Intestinal glucose absorption is integral to postprandial glucose homeostasis. Glucose absorption is dependent on a number of factors, including the exposure of carbohydrate to the mucosa of the upper gastrointestinal tract (determined particularly by the rates of gastric emptying and small intestinal transit), the digestion of complex carbohydrate into monosaccharides, and glucose sensing and transport by the intestinal mucosa. The absorption of glucose in the small intestine is not only a determinant of the appearance of exogenous glucose in the peripheral circulation, but is also coupled to the release of gastrointestinal hormones that in turn influence postprandial glucose metabolism through modulating gastrointestinal motor function, insulin and glucagon secretion, and subsequent energy intake. This review describes the physiology and pathophysiology of intestinal glucose absorption in health and type 2 diabetes, including its relevance to glucose tolerance and the management of postprandial hyperglycaemia. |
Keywords: | Intestinal Mucosa Animals Humans Diabetes Mellitus, Type 2 Glucose Intestinal Absorption |
Rights: | © 2020 Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.coph.2020.10.017 |
Grant ID: | NHMRC |
Published version: | http://dx.doi.org/10.1016/j.coph.2020.10.017 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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