Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/130094
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Retromer dysfunction at the nexus of tauopathies |
Author: | Carosi, J.M. Denton, D. Kumar, S. Sargeant, T.J. |
Citation: | Cell Death and Differentiation, 2021; 28(3):884-889 |
Publisher: | Springer Nature |
Issue Date: | 2021 |
ISSN: | 1350-9047 1476-5403 |
Statement of Responsibility: | Julian M. Carosi, Donna Denton, Sharad Kumar, Timothy J. Sargeant |
Abstract: | Tauopathies define a broad range of neurodegenerative diseases that encompass pathological aggregation of the microtubule-associated protein tau. Although tau aggregation is a central feature of these diseases, their underlying pathobiology is remarkably heterogeneous at the molecular level. In this review, we summarize critical differences that account for this heterogeneity and contrast the physiological and pathological functions of tau. We focus on the recent understanding of its prion-like behavior that accounts for its spread in the brain. Moreover, we acknowledge the limited appreciation about how upstream cellular changes influence tauopathy. Dysfunction of the highly conserved endosomal trafficking complex retromer is found in numerous tauopathies such as Alzheimer's disease, Pick's disease, and progressive supranuclear palsy, and we discuss how this has emerged as a major contributor to various aspects of neurodegenerative diseases. In particular, we highlight recent investigations that have elucidated the contribution of retromer dysfunction to distinct measures of tauopathy such as tau hyperphosphorylation, aggregation, and impaired cognition and behavior. Finally, we discuss the potential benefit of targeting retromer for modifying disease burden and identify important considerations with such an approach moving toward clinical translation. |
Keywords: | Animals Humans Neurodegenerative Diseases Tauopathies tau Proteins |
Rights: | © The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2021 |
DOI: | 10.1038/s41418-020-00727-2 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1124490 http://purl.org/au-research/grants/nhmrc/1103006 |
Published version: | http://dx.doi.org/10.1038/s41418-020-00727-2 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.