Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/131571
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dc.contributor.author | Denton, D. | - |
dc.contributor.author | O'Keefe, L. | - |
dc.contributor.author | Kumar, S. | - |
dc.contributor.editor | Martinez, A.B. | - |
dc.contributor.editor | Galluzzi, L. | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Progress in Molecular Biology and Translational Science, 2020 / Martinez, A.B., Galluzzi, L. (ed./s), vol.172, Ch.15, pp.375-409 | - |
dc.identifier.isbn | 9780128220214 | - |
dc.identifier.uri | http://hdl.handle.net/2440/131571 | - |
dc.description.abstract | Autophagy has important functions in normal physiology to maintain homeostasis and protect against cellular stresses by the removal of harmful cargos such as dysfunctional organelles, protein aggregates and invading pathogens. The deregulation of autophagy is a hallmark of many diseases and therapeutic targeting of autophagy is highly topical. With the complex role of autophagy in disease it is essential to understand the genetic and molecular basis of the contribution of autophagy to pathogenesis. The model organism, Drosophila, provides a genetically amenable system to dissect out the contribution of autophagy to human disease models. Here we review the roles of autophagy in human disease and how autophagy studies in Drosophila have contributed to the understanding of pathophysiology. | - |
dc.description.statementofresponsibility | Donna Denton, Louise O'Keefe, Sharad Kumar | - |
dc.language.iso | en | - |
dc.publisher | Academic Press | - |
dc.relation.ispartofseries | Progress in Molecular Biology and Translational Science | - |
dc.rights | © 2020 Elsevier. All rights reserved. | - |
dc.source.uri | https://www.sciencedirect.com/bookseries/progress-in-molecular-biology-and-translational-science/vol/172/suppl/C | - |
dc.subject | Animals | - |
dc.subject | Humans | - |
dc.subject | Drosophila melanogaster | - |
dc.subject | Neoplasms | - |
dc.subject | Cell Transformation, Neoplastic | - |
dc.subject | Neurodegenerative Diseases | - |
dc.subject | Lysosomal Storage Diseases | - |
dc.subject | Disease Models, Animal | - |
dc.subject | Cachexia | - |
dc.subject | Drosophila Proteins | - |
dc.subject | Tumor Suppressor Proteins | - |
dc.subject | Drug Screening Assays, Antitumor | - |
dc.subject | Organ Specificity | - |
dc.subject | DNA Repeat Expansion | - |
dc.subject | Conserved Sequence | - |
dc.subject | Homeostasis | - |
dc.subject | Mutation | - |
dc.subject | Mosaicism | - |
dc.subject | Autophagy | - |
dc.subject | Neoplastic Stem Cells | - |
dc.subject | Drug Discovery | - |
dc.subject | Imaginal Discs | - |
dc.subject | Autophagy-Related Proteins | - |
dc.subject | Infections | - |
dc.title | Drosophila as a model to understand autophagy deregulation in human disorders | - |
dc.type | Book chapter | - |
dc.identifier.doi | 10.1016/bs.pmbts.2020.01.005 | - |
dc.publisher.place | Cambridge, MA; United States | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1124490 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1103006 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP170100623 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Kumar, S. [0000-0001-7126-9814] | - |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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