Adelaide Research & Scholarship
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https://hdl.handle.net/2440/131691
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| Type: | Journal article |
| Title: | Arming androgen receptors to oppose oncogenic estrogen receptor activity in breast cancer |
| Author: | Hickey, T.E. Dwyer, A.R. Tilley, W.D. |
| Citation: | British Journal of Cancer, 2021; 125(12):1599-1601 |
| Publisher: | Springer Nature |
| Issue Date: | 2021 |
| ISSN: | 0007-0920 1532-1827 |
| Statement of Responsibility: | Theresa E. Hickey, Amy R. Dwyer and Wayne D. Tilley |
| Abstract: | Most breast cancers are driven by oncogenic activity of the estrogen receptor alpha (ER). Resistance to ER target therapies is the major cause of breast cancer death. Recently, there has been renewed interest in targeting the androgen receptor (AR) to treat ER-driven breast cancers. Herein, we discuss evidence for an AR agonist, not antagonist, treatment strategy. |
| Keywords: | Humans Breast Neoplasms Receptors, Androgen Receptors, Estrogen Female |
| Description: | Published online: 22 July 2021 |
| Rights: | © The Author(s), under exclusive licence to Springer Nature Limited 2021. Published on Behalf of CRUK |
| DOI: | 10.1038/s41416-021-01478-8 |
| Grant ID: | http://purl.org/au-research/grants/nhmrc/1084416 http://purl.org/au-research/grants/nhmrc/1130077 |
| Published version: | http://dx.doi.org/10.1038/s41416-021-01478-8 |
| Appears in Collections: | Aurora harvest 8 Medicine publications |
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