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https://hdl.handle.net/2440/13229
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Type: | Journal article |
Title: | Characterization of a gene encoding a cysteine-rich keratin associated protein synthesized late in rabbit hair follicle differentiation |
Author: | Powell, B. Arthur, J. Nesci, A. |
Citation: | Differentiation, 1995; 58(3):227-232 |
Publisher: | Springer-Verlag |
Issue Date: | 1995 |
ISSN: | 0301-4681 1432-0436 |
Abstract: | Many different cysteine-rich proteins are synthesized during hair follicle differentiation, forming part of the interstitial matrix between bundles of intermediate filaments. We have isolated a rabbit gene (rKAP4L¹), a member of a multi gene family that encodes a small cysteine-rich hair keratin associated protein. This is the first complete gene sequence for this family. The rKAP4L gene is expressed in the cortex of rabbit pelage hair follicles at a late stage of hair follicle differentiation, well after the synthesis of the other major hair proteins, the intermediate filament and glycine/tyrosine-rich keratin associated proteins, has commenced. The protein contains 36 mol % cysteine, with a molecular size of 13593 daltons, and its sequence appears to be based on a pentapeptide repeat. It is predicted to adopt a folded conformation characterized by β-turns interspersed with short stretches of β-sheet or random coil |
Keywords: | Hair Animals Sheep Rabbits Cysteine Proteins In Situ Hybridization Chromosome Mapping Cell Differentiation Gene Expression Amino Acid Sequence Base Sequence Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Multigene Family Molecular Sequence Data Keratins |
Description: | Copyright © 1999-2009 John Wiley & Sons, Inc. All Rights Reserved. |
DOI: | 10.1046/j.1432-0436.1995.5830227.x |
Published version: | http://www3.interscience.wiley.com/journal/119247207/abstract |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 7 |
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