Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/13236
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Characterization of the EphA1 receptor tyrosine kinase: Expression in epithelial tissues |
Author: | Coulthard, M. Lickliter, J. Subanesan, N. Chen, K. Webb, G. Lowry, A. Koblar, S. Bottema, C. Boyd, A. |
Citation: | Growth Factors, 2001; 18(4):303-317 |
Publisher: | Harwood Acad Publ GMBH |
Issue Date: | 2001 |
ISSN: | 0897-7194 1029-2292 |
Organisation: | Centre for the Molecular Genetics of Development |
Abstract: | The Eph family of receptor tyrosine kinases plays a crucial role during development and is implicated in oncogenesis. Using a partial cDNA clone of an Eph-related kinase (Esk) we isolated the complete coding region of a gene which we show to be murine EphA1 by both structural and functional criteria. The chromosomal localization is shown to be syntenic to hEphA1 and the genomic organization also shows distinct features found in the hEphA1 gene. Functionally, in keeping with findings for the human homologue, both soluble recombinant and "native" mEphA1 show preferential binding to ephrin A1. However, we also observed significant binding to other A-type ligands as has been observed for other Eph receptors. We analysed the expression of mEphA1 mRNA by in situ hybridization on tissue sections. mEphA1 was expressed in epithelial elements of skin, adult thymus, kidney and adrenal cortex. Taken together with previous Northern blotting data these results suggest that mEphA1 is expressed widely in differentiated epithelial cells. |
Keywords: | Eph receptor tyrosine kinase epithelial tissue genomic organisation thymus |
DOI: | 10.3109/08977190109029118 |
Published version: | http://dx.doi.org/10.3109/08977190109029118 |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 7 Centre for the Molecular Genetics of Development publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.